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In silico thrombectomy trials for acute ischemic stroke
Computer Methods and Programs in Biomedicine, 2023 In silico trials aim to speed up the introduction of new devices in clinical practice by testing device design and performance in different patient scenarios and improving patient stratification for optimizing clinical trials. In this paper, we demonstrate an in silico trial framework for thrombectomy treatment of acute ischemic stroke and apply this ...
Claire Miller +2 more
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In Silico Clinical Trials: Is It Possible?
2023Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug research and development and reduce costs and have coined the term "model-informed drug development (MIDD)." Data-driven, inferential approaches are now becoming increasingly complemented by emerging complex physiologically and knowledge-based disease (and drug)
Simon, Arsène +16 more
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In-Silico Clinical Trials as a New Paradigm in Medicine
2020 9th Mediterranean Conference on Embedded Computing (MECO), 2020In silico clinical trial represents a new paradigm for development of new drug and medical device. In SILICOFCM project Familial Cardiomyopathy disease was modelled with comprehensive list of patient specific features such as genetic, biological, pharmacologic, clinical, imaging.
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Identifying the patient harms to include in an in silico clinical trial
Computer Methods and Programs in Biomedicine, 2023Clinical trials represent a crucial step in the development and approval of medical devices. These trials involve evaluating the safety and efficacy of the device in a controlled setting with human subjects. However, traditional clinical trials can be expensive, time-consuming, and ethically challenging.
Philippe Favre, Jeff Bischoff
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In Silico Trial Approach for Biomedical Products: A Regulatory Perspective
Combinatorial Chemistry & High Throughput Screening, 2022Abstract: The modern pharmaceutical industry is transitioning from traditional methods to advanced technologies like artificial intelligence. In the current scenario, continuous efforts are being made to incorporate computational modeling and simulation in drug discovery, development, design, and optimization.
Jobin Jose +3 more
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Computational model of tumor growth for in silico trials
Medical Imaging 2021: Physics of Medical Imaging, 2021Digital breast tomosynthesis (DBT) can improve the detectability of breast cancer by eliminating overlapping breast tissues that affects the performance of digital mammography (DM) systems. It is yet to be established if DBT can detect lesions at earlier progression stages than DM.
Aunnasha Sengupta +2 more
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