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In Silico Clinical Trials for Cardiovascular Disease.
Journal of visualized experiments : JoVE, 2022The SILICOFCM project mainly aims to develop a computational platform for in silico clinical trials of familial cardiomyopathies (FCMs). The unique characteristic of the platform is the integration of patient-specific biological, genetic, and clinical imaging data.
Nenad, Filipovic +7 more
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Advancing in Silico Clinical Trials for Regulatory Adoption and Innovation
IEEE Journal of Biomedical and Health InformaticsThe evolution of information and communication technologies has affected all fields of science, including health sciences. However, the rate of technological innovation adoption by the healthcare sector has been historically slow, compared to other industrial sectors.
Georgia S Karanasiou +2 more
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In silico design of clinical trials: A method coming of age
Critical Care Medicine, 2004To determine the feasibility and potential usefulness of mathematical models in evaluating immunomodulatory strategies in clinical trials of severe sepsis.Mathematical modeling of immunomodulation in simulated patients.Computer laboratory.We introduce and evaluate the concept of conducting a randomized clinical trial in silico based on simulated ...
Gilles, Clermont +5 more
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In silico environments augment clinical trials
IEEE Engineering in Medicine and Biology Magazine, 1996One of the most promising new approaches to interpreting complex systems data is to generate self-organizing simulations. We have previously applied Markov random field methods to create virtual worlds for the prototyping of wetlab experimentation.
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In-silico pre-clinical trials for implantable cardioverter defibrillators
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven ...
Zhihao Jiang +6 more
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Integrating machine learning into the in silico clinical trial pipeline
Mathematical BiosciencesIn silico clinical trials offer a powerful tool for overcoming several limitations of traditional clinical trials. Conventional trials are time- and resource-intensive, typically designed to assess average effects across a population while being restricted to studying the impact of a fixed treatment protocol.
Rebecca A. Bekker +4 more
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In Silico Trials and Personalized Therapy for Sepsis and Trauma
2013Randomized, placebo-controlled clinical trials are the current gold standard for proof of clinical efficacy of a given drug or device. Unfortunately, recent history is littered with therapeutics being withdrawn despite having been “proven” efficacious and safe in pivotal (Phase III) clinical trials. Moreover, many drug candidates fail at various stages
Yoram Vodovotz, John Bartels, Gary An
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Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices
IEEE Journal of Biomedical and Health Informatics, 2022Francesco Pappalardo +2 more
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Possible Contexts of Use for In Silico Trials Methodologies: A Consensus-Based Review
IEEE Journal of Biomedical and Health Informatics, 2021Marco Viceconti +2 more
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