Results 61 to 70 of about 112,390 (279)

Strategies for recovering exact structure of neural circuits with broadly targeted fluorescent connectivity probes [PDF]

, 2009
We present a framework for reconstructing structure of complete neural circuits in the brain using collections of independent measurements of connectivity performed with existing anatomical or functional fluorescent probes, and
Yuriy Mishchenko
core   +1 more source

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]

, 2019
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Combining genetic proxies of drug targets and time-to-event analyses from longitudinal observational data to identify target patient populations

BMC Cardiovascular Disorders
Background Human genetics is an important tool for identifying genes as potential drug targets, and the extensive genetic study of cardiovascular disease provides an opportunity to leverage genetics to match specific patient populations to specific drug ...
Luke Zhang, Prachi Kulkarni, Farshad Farshidfar, Whit Tingley, Tim Hoey, Whedy Wang, James R. Priest, Sylwia M. Figarska   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Moving forward through the in silico modeling of multiple sclerosis: Treatment layer implementation and validation

Computational and Structural Biotechnology Journal, 2023
Multiple sclerosis is an autoimmune inflammatory disease that affects the central nervous system through chronic demyelination and loss of oligodendrocytes.
Avisa Maleki, Elena Crispino, Serena Anna Italia, Valentina Di Salvatore, Maria Assunta Chiacchio, Fianne Sips, Roberta Bursi, Giulia Russo, Davide Maimone, Francesco Pappalardo   +9 more
doaj   +1 more source

The promise of cardiomyocyte computational models for drug safety [PDF]

Military Medical Research
Lei Wang, Blanca Rodriguez
doaj   +2 more sources

Modelling of Tirapazamine effects on solid tumour morphology [PDF]

, 2011
Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive ...
A.I. Minchinton, A.J. Perumpanani, A.M. Shannon, B.G. Siim, E. Lartigau, F. Kozusko, H. Enderling, H.M. Byrne, J. Folkman, J. Vohardsky, J.J. Kim, J.M. Brown, J.M. Brown, L. Marcu, L. Preziosi, L.H. Patterson, N. Ferrara, R.E. Durand, S.M. Tse   +18 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim

BMC Medical Informatics and Decision Making, 2022
Background The last few decades have seen the approval of many new treatment options for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic methodology and criteria.
Fianne L. P. Sips, Francesco Pappalardo, Giulia Russo, Roberta Bursi   +3 more
doaj   +1 more source