Results 61 to 70 of about 115,018,110 (301)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate

Journal of Applied Pharmaceutical Research, 2021
The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug.
Shaikh Shoaeba, Desai Sharav, Hitesh Jain, Asit Sahu, D. B. Meshram   +4 more
doaj   +1 more source

OntOMat: Toward Ontology‐Based Product and Process Design Engineering and Optimization Solutions Fueling Circular Value Chains

Advanced Engineering Materials, EarlyView.
The OntOMat ontology establishes a structured framework for polymer matrix fiber reinforced composite materials, integrating manufacturing processes, characterization methods, and multiscale design through the VDI/VDE 3682 formalized process description standard.
Nicolas Christ, Jörg Hohe, Martin Kördel, Michael Giese, Niklas Toffert, Christian Seidel, Olaf Rehme, Patrik Schneider, Oliver Focke, Elie Abi Aoun, Claas Falldorf, Beñat Gutierrez, Alexandra Kühn, Sven Torstrick-von der Lieth, Christoph Herden, Erik Johannsen, Jan‐Uwe R. Schmidt, Felix Winkelmann, Andreas Schott, Daniel Schott   +19 more
wiley   +1 more source

Physical study of Chloramphenicol In Situ Gel with Base Hydroxypropyl Methylcellulose and Poloxamer 188

Journal of Pharmacy and Bioallied Sciences, 2019
Objective: The aim of this study was to determine the best formulation of ophthalmic in situ gel preparation by two different bases, Poloxamer 188 and HPMC (hydroxypropyl methylcellulose), with physical evaluation, such as organoleptic, pH, viscosity ...
Insan S Kurniawansyah, Dolih Gozali, Iyan Sopyan, Muhammad Iqbal, Anas Subarnas   +4 more
doaj   +1 more source

The development of an in-situ biopolymer-based floating gel for the oral delivery of metformin hydrochloride

Heliyon, 2023
Diabetes remains a global public health threat because of its increasing prevalence and mortality, especially in people under the age of 25. Metformin hydrochloride (HCl), as recommended by American Diabetes Association in 2022, is the first-line therapy
Ruedeekorn Wiwattanapatapee, Kalayamas Klabklay, Nontawat Raksajit, Worrawee Siripruekpong, Nattawut Leelakanok, Arpa Petchsomrit   +5 more
doaj   +1 more source

Development and Characterization ofIn SituOral Gel of Spiramycin [PDF]

BioMed Research International, 2014
The present investigation deals with the optimization, formulation, and characterization of oralin situgel of spiramycin. Sodium alginate and hydroxypropyl methylcellulose were used as cross-linking and viscosifying agents, respectively. Sodium bicarbonate was used as a floating agent.
Sharma, Avinash, Sharma, Jyoti, Kaur, Rupinder, Saini, Vinay   +3 more
openaire   +2 more sources

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

In-Situ Gel-New Formulation Trend

International Journal of Scientific Research in Science and Technology, 2022
This review on in situ gel was written to fill in any gaps in the current body of knowledge, with a special emphasis on in-situ gelling systems that prolong the residence time of drugs at their targets. Drugs with very short half-lives and high solubility are especially interested in in-situ gels.
Dhage, Azad Nabilal, Mulla, Zinat Isak, Kulkarni, Abhijeet Shashikant, Borge, Aniket Ramesh, Ghosalkar, Mayur Krishnat   +4 more
openaire   +1 more source

In Situ XRD and TEM Studies of Sol-Gel-Based Synthesis of LiFePO₄

, 2016
Parallel in situ TEM and XRD heating experiments of LiFePO4 precursors obtained by sol-gel method were conducted to study changes and to understand structural and morphological evolution during synthesis annealing, which is one of the most critical ...
Bartosz Hamankiewicz (3032661), Andrzej Czerwinski (1343649), Jacek B. Jasinski (1489663), Dominika A. Ziolkowska (3032655), She-Huang Wu (3032658), Krzysztof P. Korona (3032664)   +5 more
core   +1 more source