Results 41 to 50 of about 193,900 (263)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Preparation and Characterization of Ion-Sensitive Brimonidine Tartrate In Situ Gel for Ocular Delivery

Pharmaceuticals, 2023
Brimonidine tartrate (BRT) is a highly selective α2 adrenergic receptor agonist as treatment for patients with open angle glaucoma and high intraocular pressure.
Haonan Xu, Ye Liu, Lu Jin, Xu Chen, Xinghao Chen, Qiao Wang, Zhan Tang   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effect of different mucoadhesive polymers on release of ondansetron HCl from intranasal mucoadhesive in situ gel

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018
The aim of this work was to promote an intranasal mucoadhesive drug allocation system to simplify the systemic delivery of ondansetron HCL (OND-HCl) for the immediate and sustain prevention of repeated nausea and vomiting caused by the initial and ...
Nidhal K. Maraie, Yasser Qasim Almajidi
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Formulation and evaluation of in situ ophthalmic gel of loteprednol etabonate

Journal of Applied Pharmaceutical Research, 2021
The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug.
Shaikh Shoaeba, Desai Sharav, Hitesh Jain, Asit Sahu, D. B. Meshram   +4 more
doaj   +1 more source

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application.
Xiaomin Ni, Qin Guo, Yiqing Zou, Yang Xuan, Imran Shair Mohammad, Qing Ding, Haiyan Hu   +6 more
doaj   +1 more source

A Review on In-Situ Nasal Gel

International Journal of Research and Review
In situ gelling drug delivery techniques have garnered a lot of interest in the last ten years. When exposed to a range of endogenous stimuli, such as temperature increases, pH shifts, and the presence of ions, they can gel from their sol-state prior to injection.
Krutika S. Nilwani, Hemalata Wadkar, Aishwarya R. Ghanwat, Shital P. Narwade   +3 more
openaire   +1 more source

Novel Details of Calsequestrin Gel Conformation in Situ [PDF]

Journal of Biological Chemistry, 2013
Calsequestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardiac muscles. This calcium-binding protein localizes to the junctional SR (jSR) cisternae, where it is responsible for the storage of large amounts of Ca(2+), whereas it is usually absent, at least in its polymerized form, in the free SR.
Perni, S., Close, M., Franzini-Armstrong, C.   +2 more
openaire   +4 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source