Results 1 to 10 of about 55,450 (217)
Updates on Biodegradable Formulations for Ocular Drug Delivery
Pharmaceutics, 2023 The complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes.
Da-Wen Lu, Ta-Hsin Tsung
exaly +3 more sources
Discovery and Potential Utility of a Novel Non-Invasive Ocular Delivery Platform [PDF]
Pharmaceutics, 2023 To this day, the use of oily eye drops and non-invasive retinal delivery remain a major challenge. Oily eye drops usually cause ocular irritation and interfere with the normal functioning of the eye, while ocular injections for retinal drug delivery ...
Weizhen (Jenny) Wang, Nonna Snider
doaj +2 more sources
Heliyon, 2023 Soft contact lenses are increasingly being explored as a vehicle for controlled delivery of ophthalmic drugs. However, traditional methods of drug-loading by soaking have limitations such as burst delivery and the release of drugs at the front side of ...
Malake Sarmout +4 more
doaj +1 more source
Pharmaceutics, 2023 Injectable polymer microparticles with the ability to carry and release pharmacologically active agents are attracting more and more interest. This study is focused on the chemical synthesis, characterization, and preliminary exploration of the utility ...
Meitong Shen, Ling Zheng, Leo H. Koole
doaj +1 more source
Scientific Reports, 2021 Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment.
Yong Yao Chun +8 more
doaj +1 more source
A Review on Conventional and Novel Topical Ocular Drug Delivery System
Journal of Pharmacy, 2021 Ocular drug delivery is a very challenging area for ophthalmologists and drug delivery scientists due to the structural and barrier complexity of the eye.
Mohamad Faeznudin Rozi +1 more
doaj +1 more source
Revolutionizing ocular drug delivery: recent advancements in in situ gel technology
Bulletin of the National Research Centre, 2023 Background Ophthalmic in situ gel is a novel preparation. It can be instilled into the eye as a liquid but gels upon contact with the ocular surface, generating a sustained-release depot of the drug.
Susanta Paul +2 more
doaj +1 more source
Disease Models & Mechanisms, 2017 Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma filtration surgery (GFS).
Li-Fong Seet +5 more
doaj +1 more source
Pharmaceutics, 2023 Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations ...
Letizia Pelusi +6 more
doaj +1 more source
Nanotechnology-based ocular drug delivery systems: recent advances and future prospects
Journal of Nanobiotechnology, 2023 Ocular drug delivery has constantly challenged ophthalmologists and drug delivery scientists due to various anatomical and physiological barriers. Static and dynamic ocular barriers prevent the entry of exogenous substances and impede therapeutic agents'
Shiding Li, Liangbo Chen, Yao Fu
doaj +1 more source