Results 11 to 20 of about 1,510,441 (262)

Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances

Pharmaceutics, 2022
Due to complicated anatomical and physical properties, targeted drug delivery to ocular tissues continues to be a key challenge for formulation scientists.
Shery Jacob, Anroop B. Nair, Jigar Shah, Sumeet Gupta, Sai H. S. Boddu, Nagaraja Sreeharsha, Alex Joseph, Pottathil Shinu, Mohamed A. Morsy   +8 more
doaj   +2 more sources

How to Fabricate Hyaluronic Acid for Ocular Drug Delivery

Pharmaceutics
This review aims to examine existing research on the development of ocular drug delivery devices utilizing hyaluronic acid (HA). Renowned for its exceptional biocompatibility, viscoelastic properties, and ability to enhance drug bioavailability, HA is a ...
Martha Kim, Mi-Young Jung, Do-Yeon Lee, So Min Ahn, Gyeong Min Lee, Choul Yong Park   +5 more
doaj   +2 more sources

Chitosan-Coated SLN: A Potential System for Ocular Delivery of Metronidazole. [PDF]

Pharmaceutics, 2023
Ophthalmic drops for ocular delivery exhibit inadequate residence time, which often requires multiple daily dosing that may result in patient non-adherence.
Sikhondze SS, Makoni PA, Walker RB, Khamanga SMM.   +3 more
europepmc   +2 more sources

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery [PDF]

, 2020
Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed.
Sadeghi, Amir, Sarkhel, Sanjay, Bahrpeyma, Sina, Toropainen, Elisa, Auriola, Seppo, Bhattacharya, Madhushree, Hagström, Marja, Urtti, Arto   +7 more
core   +1 more source

Polysaccharides in Ocular Drug Delivery [PDF]

, 2019
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies.
Arto Urtti, Skorik, Yury A., Yury A. Skorik, Poshina, Daria, Urtti, Arto, Dubashynskaya, Natallia, Raik, Sergei, Sergei Raik, Daria Poshina, Natallia Dubashynskaya   +9 more
core   +1 more source

Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions

Micromachines, 2023
Drug delivery to the anterior and posterior segments of the eye is impeded by anatomical and physiological barriers. Increasingly, the bioeffects produced by ultrasound are being proven effective for mitigating the impact of these barriers on ocular drug
Blair Duncan, Raida Al-Kassas, Guangming Zhang, Dave Hughes, Yongqiang Qiu   +4 more
doaj   +1 more source

Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies

, 2021
Posaconazole (PSC) is a triazole group anti-fungal agent with the widest spectrum. Although there is no commercially available ocular dosage form, its diluted oral suspension preparation (Noxafil (R)) is used as off-label in topical treatment of severe ...
Gungor, Sevgi, Hacioglu, Mayram, Ozsoy, Yildiz, Durgun, Meltem Ezgi, Kahraman, Emine   +4 more
core   +1 more source

Dynamic Ex Vivo Porcine Eye Model to Measure Ophthalmic Drug Penetration under Simulated Lacrimal Flow

Pharmaceutics, 2023
Animal models are still used in the research and development of ophthalmic drug products, mainly due to the difficulty in simulating natural physiological conditions with in vitro models, as there is a lack of dynamic protection mechanisms.
Geisa N. Barbalho, Manuel A. Falcão, Jefferson M. S. Lopes, Júlia M. Lopes, Jonad L. A. Contarato, Guilherme M. Gelfuso, Marcilio Cunha-Filho, Tais Gratieri   +7 more
doaj   +1 more source

Ophthalmic Drug Delivery, 2nd Edition

, 2023
Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety.

core   +1 more source

Enhancing Ocular Bioavailability of Ciprofloxacin Using Colloidal Lipid-Based Carrier for the Management of Post-Surgical Infection

Molecules, 2022
Conjunctivitis and endogenous bacterial endophthalmitis mostly occurred after ophthalmic surgery. Therefore, the present study aimed to maximize the ocular delivery of ciprofloxacin (CPX) using colloidal lipid-based carrier to control the post-surgical ...
Fakhria A. Al-Joufi, Mounir M. Salem-Bekhit, Ehab I. Taha, Mohamed A. Ibrahim, Magdy M. Muharram, Sultan Alshehri, Mohammed M. Ghoneim, Faiyaz Shakeel   +7 more
doaj   +1 more source