Results 41 to 50 of about 1,510,441 (262)

Epidemiological study of ocular trauma in an urban slum population in Delhi, India. [PDF]

, 2008
PURPOSE: To study the epidemiology and clinical profile of victims of ocular trauma in an urban slum population. MATERIALS AND METHODS: This cross-sectional study, conducted on 500 families each in three randomly selected urban slums in Delhi, collected ...
Vats, S, Gupta, SK, Vashist, P, Chandra, M, Gogoi, M, Murthy, GVS   +5 more
core   +1 more source

Drug Delivery Systems for Infectious Eye Diseases: Advancements and Prospects

Journal of Nanotheranostics
Infectious ocular diseases like keratitis, conjunctivitis, and endophthalmitis pose significant clinical challenges due to the complexities of delivering drugs to the eye.
Binapani Mahaling, Namrata Baruah, Aumreetam Dinabandhu   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Desenvolvimento e avaliação biofarmacêutica de sistemas coloidais como carreadores para a administração ocular do agente antitumoral 5-fluorouracil [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em FarmáciaO potencial das nanopartículas poliméricas em aumentar as oportunidades de absorção corneal após a administração tópica na ...
Reus, Márcia
core  

Solid lipid nanoparticles for ocular drug delivery.

, 2010
Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity.
John Shaw, Shaw, John, Ali Seyfoddin, Raida Al-Kassas, Seyfoddin, Ali, Al-Kassas, Raida   +5 more
core   +1 more source

Unraveling the Therapeutic Enigma of Liposomes in Ocular Drug Delivery

Journal of Bio-X Research
The ocular delivery of drugs has always presented a pharmaceutical challenge. Various ocular barriers, such as reflex blinking, tear turnover, epithelial tight junctions, metabolism in ocular tissues, efflux pumps, nasolacrimal drainage, and other blood ...
Sandip Karmakar, Sreejan Manna, Tamal Jana, Sougata Jana, Gouranga Nandi   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Formulation and Evaluation of Sustained Release Ocular Drug Delivery System for an Anti-Glaucoma Drug [PDF]

, 2013
Not ...
Gevariya, Hitesh B.
core  

Comprehensive Strategies for Overcoming Barriers in Ocular Drug Delivery: Current Trends and Future Directions

Biomedical Sciences and Clinical Medicine
The human eye is a complex and sensitive organ, making effective drug delivery a major challenge. Its anatomical barriers, such as the precorneal, corneal, and blood-ocular barriers, significantly limit drug penetration and retention.
Elavarasan N, S. Revathi, K. Venkateshwaran   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source