Results 61 to 70 of about 1,510,441 (262)

Ocular Delivery: Innovations in Ocular Inserts, Contact Lenses, and Microneedles

BIO Integration
Ocular drug delivery systems are essential for treating various eye conditions. Ocular conventional drug delivery techniques, such as eye drops (topical administration), often face challenges, like rapid drainage and low bioavailability.
Soumya Samanta, Nimisha Srivastava
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Ocuserts: A novel ocular drug delivery system [PDF]

Ocular drug delivery poses significant challenges due to the unique anatomy and physiology of the eye. Conventional dosage forms, such as eye drops, often suffer from poor bioavailability, short residence time, and frequent dosing.
Korde , Atharv V., Bakal , Ravindra L., Sune, Prathmesh S., Hiwe, Kanchan A., Hatwar , Pooja R.   +4 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Seeing the Future: A Review of Ocular Therapy

Bioengineering
Ocular diseases present a unique challenge and opportunity for therapeutic development. The eye has distinct advantages as a therapy target given its accessibility, compartmentalization, immune privilege, and size.
Maiya Whalen, Monica Akula, Shannon M. McNamee, Margaret M. DeAngelis, Neena B. Haider   +4 more
doaj   +1 more source

Ocular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection

Advanced Science, 2021
The development of potent antibiotic alternatives with rapid bactericidal properties is of great importance in addressing the current antibiotic crisis.
Mingyue Cui, Mengjia Zheng, Christian Wiraja, Sharon Wan Ting Chew, Arti Mishra, Venkatesh Mayandi, Rajamani Lakshminarayanan, Chenjie Xu   +7 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Herbal Bioactives for Ocular Drug Delivery Systems

, 2022
Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations.
Algın Yapar, Evren; Durgun, Meltem Ezgi; Esentürk, Imren; Güngör, Sevgi; Özsoy, Yıldız.
core   +1 more source

Ocular Drug, Gene and Cellular Delivery Systems and Advanced Therapy Medicinal Products [PDF]

, 2018
Due to recent advances in science and technology, when the products used in therapy are examined, ophthalmology has a priority in terms of research and development, preclinical and clinical studies of innovative drugs, medical devices and drug-medical ...
Türkan Eldem, Eldem, Bora, Bora Eldem, Eldem, Türkan   +3 more
core   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source