Results 21 to 30 of about 1,510,441 (262)

Design of an Implantable Device for Ocular Drug Delivery [PDF]

, 2012
Ocular diseases, such as, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa require drug management in order to prevent blindness and affecting million of adults in USA and worldwide.
Moorthy, Ramana S., Pidaparti, Ramana M., Lee, Jae-Hwan, Atkinson, Gary M., Lee, Jae Hwan, Pidiparti, Ramana M.   +5 more
core   +1 more source

Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies

Molecules, 2023
This study investigates the development of topically applied non-invasive amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU).
Adel Ali Alhowyan, Mohd Abul Kalam, Muzaffar Iqbal, Mohammad Raish, Ahmed M. El-Toni, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan   +7 more
doaj   +1 more source

Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

Journal of Nanobiotechnology, 2022
Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded in achieving a proper drug delivery approach
Mehrdad Afarid, Shirin Mahmoodi, Roghayyeh Baghban   +2 more
doaj   +1 more source

Lentiviral Vectors for Ocular Gene Therapy

Pharmaceutics, 2022
This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, and an overview of their use in the field of ophthalmology.
Yvan Arsenijevic, Adeline Berger, Florian Udry, Corinne Kostic   +3 more
doaj   +1 more source

Research progress of in-situ gelling ophthalmic drug delivery system

Asian Journal of Pharmaceutical Sciences, 2019
Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various ...
Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawei Li, Shouying Du, Zhidong Liu   +9 more
doaj   +1 more source

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Gels, 2022
In the present study, erythromycin (EM)-loaded nanostructured lipid carriers (NLCs) were prepared by the emulsification and ultra-sonication method. EM-NLCs were optimized by central composite design using the lipid (A), pluronic F127 (B) and sonication ...
Ameeduzzafar Zafar, Syed Sarim Imam, Mohd Yasir, Nabil K. Alruwaili, Omar Awad Alsaidan, Musarrat Husain Warsi, Shehla Nasar Mir Najib Ullah, Sultan Alshehri, Mohammed M. Ghoneim   +8 more
doaj   +1 more source

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

, 2020
Sufficient ophthalmic drug delivery is still challenging for pharmaceutical technologists, despite various scientific efforts. Several ocular drug carriers have been designed to enhance bioavailability by prolonging the drug retention time.
Okur, Neslihan Ustundag, Caglar, Emre Sefik, Siafaka, Panoraia   +2 more
core   +1 more source

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Pharmaceutics, 2018
The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach.
Marion Dubald, Sandrine Bourgeois, Véronique Andrieu, Hatem Fessi   +3 more
doaj   +1 more source

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Pharmaceutics, 2022
The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules.
Elide Zingale, Alessia Romeo, Salvatore Rizzo, Cinzia Cimino, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci, Rosario Pignatello   +7 more
doaj   +1 more source

A NOVEL APPROACHES ON OCULAR DRUG DELIVERY SYSTEM [PDF]

, 2017
The purpose of this review is giving a current update of the knowledge in this field of ocular drug delivery. The ocular drug delivery has been a major challenge to drug delivery scientists mainly due to its unique anatomy and physiology.
Kothapalli, Chandrasekhar B, Reddigari, Jayachandra Reddy Peddappi, Ramesh, Yerikala   +2 more
core   +1 more source