Results 281 to 290 of about 2,801,410 (319)

Fluorescence in situ hybridization: A brief review

Environmental and Molecular Mutagenesis, 1996
Fluorescence in situ hybridization (FISH) is used for many purposes, including analysis of chromosomal damage, gene mapping, clinical diagnostics, molecular toxicology and cross-species chromosome homology. FISH allows an investigator to identify the presence and location of a region of cellular DNA or RNA within morphologically preserved chromosome ...
Roy R. Swiger, James D. Tucker
openaire   +3 more sources

Blaming the Right Fluorescent in Situ Hybridization

Journal of Clinical Oncology, 2015
TO THE EDITOR: Bochtler et al have observed that patients with light chain (AL) amyloidosis with t(11;14) fare worse with bortezomib-based therapy. This observation is difficult to reconcile given both the fact that a majority of patients with AL have t(11;14), and that bortezomib has been observed to be a highly effective therapy in patients with AL ...
Angela Dispenzieri, Rahma Warsame
openaire   +3 more sources

Fluorescence in situ Hybridization in Cytopathology

2020
The application of ancillary studies to small biopsies and cytopathology specimens has been increasing for definitive diagnoses and theranostic information. Fluorescence in situ hybridization (FISH) is one of the ancillary techniques being applied to these small specimens, and has been utilized with great success for years, particularly in the ...
Sanja Dacic, Sara E. Monaco
openaire   +2 more sources

Fluorescence In Situ Hybridization and Comparative Genomic Hybridization

2006
This chapter discusses the complementary methodologies of fluorescence in situ hybridization and comparative genomic hybridization. Fluorescence in situ hybridization uses fluorescently labeled DNA probes (whole chromosomes, centromere, or locus-specific sequences) to visualize complementary DNA sequences in the target DNA (metaphase chromosomes or ...
Patricia Gorman, Rebecca Roylance
openaire   +3 more sources

Fluorescence In Situ Hybridization and In Situ PCR

2011
The application of fluorescence in situ hybridization to chromosomes allows each member of the karyotype to be distinguished from all others. This technique can be used to detect changes in chromosomes. Individual genes and transgenes can be placed to chromosome as well.
James A. Birchler, Tatiana V. Danilova
openaire   +2 more sources

Fluorescence in situ hybridization in diagnostic cytology

Human Pathology, 2007
Fluorescence in situ hybridization (FISH) is a technique that uses fluorescently labeled DNA probes to detect chromosomal alterations in cells. FISH can detect various types of cytogenetic alterations including aneusomy (ie, abnormalities of chromosome copy number), duplication, amplification, deletion, and translocation.
Benjamin R. Kipp, Kevin C. Halling
openaire   +3 more sources

Fluorescence In Situ Hybridization

2001
There is a rumor that goes like this: After a particularly successful day at an international genetics conference in the late 1960s in Scotland, delegates rewarded themselves with the customary pint of beer at their favorite watering hole, the public house.
openaire   +2 more sources

Clinical applications of fluorescence in situ hybridization

Genetic Analysis: Biomolecular Engineering, 1991
We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection.
Daniel Pinkel, Joe W. Gray, D. Tkachuk, Wen Lin Kuo, H.-U. Weier   +4 more
openaire   +3 more sources

fluorescence in situ hybridization

2017
Fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique used to physically map DNA sequences on chromosomes. In FISH, DNA probes are most often hybridized to target DNA in metaphase chromosomes spread on slides (in situ). FISH probes are variable in size.
openaire   +2 more sources

Fluorescence In Situ Hybridization in Oat

2017
This chapter describes methods to detect gene loci or gene transcripts by fluorescence labeling. Fluorescence in situ hybridization (FISH) can be used to identify the positions of genes or BACs or the distribution of repetitive sequences on metaphase chromosomes as well as the identification of alien chromosomes.
openaire   +3 more sources