Results 91 to 100 of about 11,428 (247)

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied

International Journal of Nanomedicine, 2020
Jing-Yi Ye,1 Zhong-Yun Chen,1 Chuan-Li Huang,1 Bei Huang,2 Yu-Rong Zheng,2 Ying-Feng Zhang,1 Ban-Yi Lu,2 Lin He,2 Chang-Shun Liu3 ,* Xiao-Ying Long1,4, * 1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People’s Republic ...
Ye JY, Chen ZY, Huang CL, Huang B, Zheng YR, Zhang YF, Lu BY, He L, Liu CS, Long XY   +9 more
doaj  

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology [PDF]

, 2015
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing.
Bouwstra, Joke, Caloni, Francesca, Constant, Samuel, Dandekar, Gudrun, Daneshian, Mardas, Davies, Donna E., Fabian, Eric, Gordon, Sarah, Guzman, Carlos A., Haltner, Eleonore, Hartung, Thomas, Hasiwa, Nina, Hayden, Patrick, Kandarova, Helena, Khare, Sangeeta, Kneuer, Carsten, Krug, Harald F., Lehr, Claus-Michael, Leist, Marcel, Lian, Guoping, Marx, Uwe, Metzger, Marco, Ott, Katharina, Prieto, Pilar, Roberts, Michael S., Roggen, Erwin L., Tralau, Tewes, van den Braak, Claudia, Walles, Heike   +28 more
core   +4 more sources

Bimetallic Nanozymes/Polypyrrole/Methylene Blue Platform for Photothermal and Catalytic Biofilm Disruption and Angiogenesis Enhancement in Diabetic Wound Healing

Small Science, EarlyView.
The bimetallic ceria‐zinc nanoflowers coated with polypyrrole and loaded with methylene blue disrupt methicillin‐resistant Staphylococcus aureus biofilms synergistically, promote angiogenesis, thereby achieving efficient diabetic wound healing. Integrated photothermal therapy optimized, photodynamic therapy enhanced, pH‐mediated multifunctional ...
Prafful P. Kothari, Tonmoy Banerjee, Balaram Ghosh, Swati Biswas   +3 more
wiley   +1 more source

Recent advances of non‐invasive sensors for smart wearable respiratory monitoring

VIEW, EarlyView.
Respiration contains rich physiological and pathological information, making it one of the most fundamental and continuous vital signs. Respiration monitoring is a non‐invasive and simple, but incredibly powerful, tool for assessing health, managing disease, and tracking fitness.
Jianhui Chen, Baoxiang Yang, Chang Peng, Bao Yang, Licheng Zhou, Zhenyu Jiang, Zejia Liu, Yiping Liu, Liqun Tang   +8 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Inhibition of P-glycoprotein expression and function by anti-diabetic drugs gliclazide, metformin, and pioglitazone in vitro and in situ

Research in Pharmaceutical Sciences, 2016
P-glycoprotein (P-gp) is a trans-membrane drug efflux pump. Several drugs are P-gp substrates. Some drugs may affect the activity of P-gp by inhibiting its function, resulting in significant drug-drug interactions (DDIs).
Mehran Mesgari Abbasi, Hadi Valizadeh, Hamed Hamishehkar, Parvin Zakeri-Milani   +3 more
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Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]

, 2018
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan, Catherine Communal, Christi D. Cook, Christian Maass, Collin D. Edington, Cynthia L. Stokes, David J. Hughes, David L. Trumper, Douglas A. Lauffenburger, Duncan Freake, Emily Geishecker, Emily Suter, Gaurav Rohatgi, Iris Lee, Jared Kirschner, Jason Velazquez, Jeremy J. Velazquez, Jiajie Yu, Jorge Valdez, Julia P. Papps, Laurie A. Boyer, Linda G. Griffith, Linda Stockdale, Luis R. Soenksen, Mario Gamboa, Matthew E. LaBarge, Michael Shockley, Murat Cirit, Nicholas Vann, Nikolaos Tsamandouras, Rebecca L. Carrier, Stephen Snyder, Steven R. Tannenbaum, Timothy Kassis, Tom Parent, Wen Li Kelly Chen, Xin Wang, Zhe Zhong   +37 more
core   +2 more sources

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Drug Design, Development and Therapy, 2015
Jin-Yang Shen,1,* Xiao-Lin Yang,2,* Zhong-Lin Yang,1 Jun-Ping Kou,1 Fei Li11State Key Laboratory of Natural Medicines, China Pharmaceutical University, 2Key Laboratory of Pharmaceutical and Biological Marine Resources Research and Development of Jiangsu ...
Shen JY, Yang XL, Yang ZL, Kou JP, Li F
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