Results 31 to 40 of about 11,428 (247)

The absorption of oral morroniside in rats: In vivo, in situ and in vitro studies

Acta Pharmaceutica, 2019
Morroniside is one of the most important iridoid glycosides from Cornus officinalis Sieb. et Zucc. In the present study, the pharmacokinetics and bioavailability studies of morroniside were conducted on Sprague-Dawley (SD) rats.
Xiong Shan, Li Jinglai, Mu Yanling, Zhang Zhenqing   +3 more
doaj   +1 more source

INTESTINAL SINGLE-PASS IN SITU PERFUSION TECHNIQUE IN RAT: THE INFLUENCE OF L-CARNITINE ON ABSORPTION OF 7-METHOXYTACRINE [PDF]

Biomedical Papers, 2005
7-Methoxytacrine (7-MEOTA) is an acetylcholine-esterase inhibitor that is potentially useful in the therapy of some neurodegenerative disorders. L-carnitine (CRT) is a naturally occuring compound that is known to increase penetration of some compounds through biological barriers.
Martin, Kunes, Zbynĕk, Svoboda, Jaroslav, Kvĕtina, Vladimír, Herout, Josef, Herink, Jirí, Bajgar   +5 more
openaire   +2 more sources

Enhancing biopharmaceutical performance of an anticancer drug by long chain PUFA based self-nanoemulsifying lipidic nanomicellar system. [PDF]

, 2017
The aim of this study was to develop polyunsaturated fatty acid (PUFA) long chain glyceride (LCG) enriched self-nanoemulsifying lipidic nanomicelles systems (SNELS) for augmenting lymphatic uptake and enhancing oral bioavailability of docetaxel and ...
Beg, Sarwar, Burrow, Andrea Julie, Katare, O P, Kaur Khurana, Rajneet, Kaur, Satvinder, Kesherwani, Prashant, Singh, Bhupinder, Singh, Kamalinder, Vashishta, Rakesh K   +8 more
core   +1 more source

In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay

Journal of Pharmacy & Pharmaceutical Sciences, 2011
PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotecan, and to quantify the amount of its cytotoxic metabolite SN-38 that is intestinally excreted (exsorped) as a predictor of intestinal toxicity, and to ...
Abdullah Khalil Rabba, Luqin Si, Kewen Xue, Ming Li, Gao Li   +4 more
doaj   +1 more source

Developing health service delivery in a poor and marginalised community in North West Pakistan [PDF]

, 2018
Objective: To improve maternal health and reduce child mortality through developing health service delivery in a poor and marginalised community in North West Pakistan.
Bingley, Helen, Lowe, Nicola M, Medhi, Rashid, Ohly, Heather, Ul Haq, Zia, Zaman, Mukhtiar   +5 more
core   +1 more source

A newly developed and fully validated HPLC method for simultenous determination of in-situ single pass intestinal permeability of domperidone, metoprolol tartarate and phenol red

Journal of Research in Pharmacy, 2023
: One of the most popular methods for figuring out a drug’s intestinal permeability is the intestinal perfusion (SPIP) approach. Metoprolol as tartrate and phenol red are frequently utilized as reference compounds in perfusion tests to assess the ...
Saniye Özcan, E. Çağlar, M. Kaynak, N. Okur   +3 more
semanticscholar   +1 more source

A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Purpose.To determine the possible mechanism of poor bioavailability of bicyclol, and clarify the respective contribution of P- glycoprotein (P-gp) and Cytochrome 3A (CYP3A). Methods. Rat in situ single-pass intestinal perfusion and Caco-2 cell monolayer
Wei Tan, Hui Chen, Jinping Hu, Yan Li
doaj   +1 more source

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering [PDF]

, 2015
Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate ...
Alberto Rainer, Ana Perestrelo, Ana Águas, Barbulovic-Nad, Chang, Chen, Das, Frey, Giancarlo Forte, Kaushik, McAuliffe, Scannell, Xu   +12 more
core   +2 more sources

Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats

Molecules, 2014
Although linarin possesses diverse pharmacological activities, its poor oral bioavailability has been a concern for further development. The present study aimed to demonstrate the feasibility of improving the oral absorption of linarin in rats with a ...
Xinchi Feng, Youping Liu, Xin Wang, Xin Di   +3 more
doaj   +1 more source

Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

Asian Journal of Pharmaceutical Sciences, 2017
Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis.
Wenjuan Zhang, Chufan Liang, Hao Liu, Zhenbao Li, Rui Chen, Mei Zhou, Dan Li, Qing Ye, Cong Luo, Jin Sun   +9 more
doaj   +1 more source