Results 1 to 10 of about 8,610,712 (380)

Suspended hydrogel culture as a method to scale up intestinal organoids

Scientific Reports, 2023
Primary tissue-derived epithelial organoids are a physiologically relevant in vitro intestinal model that have been implemented for both basic research and drug development applications.
Julia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan   +3 more
doaj   +1 more source

Characterization of highly expressed novel hub genes in hepatitis E virus chronicity in rabbits: a bioinformatics and experimental analysis

BMC Veterinary Research, 2022
Background Hepatitis E virus (HEV), which is the leading cause of acute viral hepatitis worldwide, usually causes self-limited infections in common individuals. However, it can lead to chronic infection in immunocompromised individuals and its mechanisms
Manyu Li, Yan Wang, Kejian Li, Haiyun Lan, Cheng Zhou   +4 more
doaj   +1 more source

Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice

Reproductive Medicine and Biology, 2022
Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma, Jasmin Primus, Bettina Wagner, Veronika Broukal, Lill Andersen, Barbara Pachner, Maik Dahlhoff, Thomas Rülicke, Kerstin E. Auer   +8 more
doaj   +1 more source

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Cell Research, 2020
Dear Editor, In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood market in Wuhan.
Manli Wang, Ruiyuan Cao, Lei-ke Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhènglì Shí, Zhìhóng Hú, Wu Zhong, Gengfu Xiao   +9 more
semanticscholar   +1 more source

Comparison of immediate versus delayed frozen embryo transfer on reproductive outcome

Clinical and Experimental Obstetrics & Gynecology, 2021
The aim of this study was to compare impact of immediate versus delayed frozen frozen embryo transfer on reproductive outcome in patients undergoing IVF treatment.
Arzu Yurci, Aret Kamar, Nurettin Turktekin, Ramazan Ozyurt   +3 more
doaj   +1 more source

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Clinical Infectious Diseases, 2020
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao, F. Ye, Miao Zhang, Cheng Cui, Baoying Huang, P. Niu, X. Liu, Li Zhao, Erdan Dong, Chunli Song, S. Zhan, R. Lu, Haiyan Li, W. Tan, Dongyang Liu   +14 more
semanticscholar   +1 more source

Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China

Open Life Sciences, 2022
Norovirus is a prominent enteric virus responsible for severe acute gastroenteritis disease burden worldwide. In our current study, we analyzed 7,804 norovirus sequences of human and animals in China which were detected from 1980 to 2020 from GenBank ...
Li Manyu, Li Kejian, Lan Haiyun, Hao Xiaotian, Liu Yan, Zhou Cheng   +5 more
doaj   +1 more source

U1 snRNP regulates cancer cell migration and invasion in vitro

Nature Communications, 2020
Stimulated cells and cancer cells have widespread shortening of mRNA 3’-untranslated regions (3’UTRs) and switches to shorter mRNA isoforms due to usage of more proximal polyadenylation signals (PASs) in introns and last exons. U1 snRNP (U1), vertebrates’
Jung-Min Oh, Christopher C. Venters, Chao Di, A. Pinto, L. Wan, Ihab Younis, Zhiqiang Cai, Chie Arai, B. So, Jingqi Duan, G. Dreyfuss   +10 more
semanticscholar   +1 more source

Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation

BMC Health Services Research, 2021
Objectives The second wave of the coronavirus pandemic is now established, occurring at a time of winter pressure on acute care in the NHS. This is likely to be more challenging then the first wave for the diagnosis of COVID-19 because of the similar ...
Timothy Hicks, Amanda Winter, Kile Green, Patrick Kierkegaard, D. Ashley Price, Richard Body, A. Joy Allen, Sara Graziadio, CONDOR Steering Group   +8 more
doaj   +1 more source

The impact of percutaneous epididymal sperm aspiration on sperm quality in mice

Reproduction and Fertility, 2023
In laboratory mice, sperm quality is usually assessed in spermatozoa collected from the cauda epididymidis of freshly sacrificed males. Percutaneous epididymal sperm aspiration (PESA) is a non-terminal alternative that would allow repeated sperm ...
Lisa Windhofer, Auke Boersma, Maik Dahlhoff, Thomas Rülicke, Kerstin E Auer   +4 more
doaj   +1 more source