Results 31 to 40 of about 535,121 (211)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Frontiers in MedicineObjectiveExploring the current status and causes of overstepping behavior among clinical research coordinators: providing reference for standardizing CRC responsibilities and safeguarding clinical trial quality and subject safety.MethodsThe research ...
Shuxia Shi +8 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Ethno Pharmacological Relevance: Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases in Southern China.Aim of the Study: The present study designed and investigated the ...
DeWen Liu +7 more
doaj +1 more source
Dermal Delivery of Niacinamide—In Vivo Studies
Pharmaceutics, 2021 In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In
Yanling Zhang +5 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Advances on cancer vaccine trials registered in China and the USA in 2014-2024
Frontiers in OncologyObjectiveThe clinical trials of cancer vaccine in China and the USA were summarized and compared over the past decade, thus putting forward suggestions for future clinical development in this field.MethodsMainly based on the Centre for Drug Evaluation of
Wei Shi +17 more
doaj +1 more source
Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution
Pharmaceutics, 2023 Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka +6 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Journal of Pharmaceutical Analysis, 2016 The present study describes the development and validation of a dissolution method for delapril (DEL) and manidipine (MAN) combination tablets, using a simulated absorption profile based on in vivo data for MAN.
Vítor Todeschini +6 more
doaj +1 more source