In Vivo Relevance of a Biphasic In Vitro Dissolution Test for the Immediate Release Tablet Formulations of Lamotrigine [PDF]
Pharmaceutics, 2023 Biphasic in vitro dissolution testing is an attractive approach to reflect on the interplay between drug dissolution and absorption for predicting the bioperformance of drug products.
Tuba Incecayir, Muhammed Enes Demir
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In Vitro Dissolution of Na-Ca-P-Oxynitrides. [PDF]
Materials (Basel), 2021 Sodium-calcium-phosphate based oxynitride glasses and glass-ceramics doped with Mg, Si, and Nb were studied in vitro in simulated body fluid (SBF) under static conditions. The release of ions and pH changes up to 7 days of immersion were investigated.
Wójcik NA +4 more
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Effects of Thickening Agents Used in Dysphagia on the In Vitro Dissolution of Gliclazide [PDF]
PharmacyDysphagia is common among older adults and frequently necessitates the use of thickening agents to facilitate safe swallowing of medicines, which may in turn alter their bioavailability.
Ayman Allahham +4 more
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Developing In Vitro–In Vivo Correlation for Bicalutamide Immediate-Release Dosage Forms with the Biphasic In Vitro Dissolution Test [PDF]
PharmaceuticsBackground/Objectives: Reflecting the interaction between dissolution and absorption, the biphasic dissolution system is an appealing approach for estimating the intestinal absorption of drugs in humans.
Nihal Tugce Ozaksun, Tuba Incecayir
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In Vitro–In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite [PDF]
Pharmaceutics, 2019 In this study a novel type of in vitro−in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug’s metabolite after the oral administration of the ...
Constantin Mircioiu +4 more
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Comparison of In Vitro and <i>In Vivo</i> Dissolution of Norvir<sup>®</sup> Oral Powder: <i>In Vivo</i> Relevance of a too Rapid <i>In Vitro</i> Dissolution Test. [PDF]
Turk J Pharm SciNorvir® oral powder [ritonavir (RTV)] employs polyvinylpyrrolidone/vinyl acetate as the polymer to formulate an amorphous solid dispersion. Its oral absolute bioavailability is 70% in the fasted state, and it has negative food effects. The aim of this study was to perform in vitro dissolution of Norvir® powder and Wagner-Nelson deconvolution of in vivo
Oktay AN, Polli JE.
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Pharmaceutics, 2019 This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling.
Tae Hwan Kim +4 more
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Pharmaceutics, 2023 A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption in ...
Christian Jede +5 more
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Development and evaluation of febuxostat solid dispersion through screening method
Saudi Pharmaceutical Journal, 2023 Febuxostat (Febux) is a BCS II drug and has a very low solubility. In order to overcome this shortcoming, the purpose of study is to increase the in vitro dissolution (%) and drug release (%) of Febux by using a screening method. The Febux-SD formulation
Jeong Sun Sohn, Jin-Seok Choi
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A BRIEF REVIEW ON PHARMACEUTICAL DISSOLUTION INTERLINKING THE ASPECTS OF SCIENCE AND REGULATION [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 Dissolution is a multistep process describes the affinity of the solute and the solvent by which a solid substance interacts among the heterogeneous phases of solute -solute, solvent-solvent, and the solute-solvent interface to yield a solution.
K Monica +2 more
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