Results 31 to 40 of about 88,172 (307)

In Vivo Predictive Dissolution (IPD) for Carbamazepine Formulations: Additional Evidence Regarding a Biopredictive Dissolution Medium

Pharmaceutics, 2020
The aim of the present study was to bring additional evidence regarding a biopredictive dissolution medium containing 1% sodium lauryl sulphate (SLS) to predict the in vivo behavior of carbamazepine (CBZ) products.
Marival Bermejo, Jessica Meulman, Marcelo Gomes Davanço, Patricia de Oliveira Carvalho, Isabel Gonzalez-Alvarez, Daniel Rossi Campos   +5 more
doaj   +1 more source

Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

CPT: Pharmacometrics & Systems Pharmacology, 2021
Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro–in vivo ...
Joyce S. Macwan, Grace Fraczkiewicz, Mauro Bertolino, Phillip Krüger, Sheila‐Annie Peters   +4 more
doaj   +1 more source

Dissolution of bioactive glass S53P4 in a three-reactor cascade in continuous flow conditions

Open Ceramics, 2023
This study expands the knowledge of bioactive glass S53P4 dissolution by implementing a cascade reactor to a continuous dissolution setup. Three reactors were coupled in a series to study the effects of released ions on S53P4 reactions in each reactor ...
Minna Siekkinen, Oskar Karlström, Leena Hupa   +2 more
doaj   +1 more source

Biorelevant Dissolution of Dipyridamole and Piroxicam Using an Automated UV/Vis Spectrophotometric and Potentiometric Dissolution Testing Platform

, 2023
The objective of this study was to investigate the implications of changing dissolution parameters, including pH ramp time, absence and presence of simulated intestinal fluid (SIF), and the addition of a partitioning phase, using an automated dissolution-
Anette Müllertz, Box, Karl, Berthelsen, Ragna, Østergaard, Jesper, Karl Box, Larsen, Susan Weng, Susan Weng Larsen, Jesper Østergaard, Müllertz, Anette, Ragna Berthelsen   +9 more
core   +1 more source

On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

Pharmaceutics, 2020
A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer, Georgios Imanidis, Karl J. Box, Christos Reppas   +3 more
doaj   +1 more source

Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets

, 2015
The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.
Ozturk, Naile, Kaynak, Mustafa Sinan, Sahin, Selma   +2 more
core   +1 more source

TIM-1 and Tiny-TIM as Robust In Vitro Models for Oral Biopharmaceutics: Evidence from an International Ring Study

Pharmaceutics
Background/Objectives: Biorelevant in vitro dissolution testing is used increasingly to predict complex mechanisms in the gastrointestinal (GI) tract that determine oral bioavailability. However, the limited use of non-compendial systems is driven by the
Connor O’Farrell, Robert Havenaar, Mark McAllister, Bart Hens, Richard Barker, Álvaro López Mármol, Andrea Ansari, Tom Ooms, Ronald Schilderink, Robert Schwabe, James Butler, Malgorzata Stróžyk, Tânia Martins Garcia, Dyko Minekus, Inese Sarcevica, Kieran Smith, Irena Tomaszewska, Eleanor Jones, Hannah Batchelor, Susann Bellmann   +19 more
doaj   +1 more source

Dissolution method for delapril and manidipine combination tablets based on an absorption profile of manidipine

Journal of Pharmaceutical Analysis, 2016
The present study describes the development and validation of a dissolution method for delapril (DEL) and manidipine (MAN) combination tablets, using a simulated absorption profile based on in vivo data for MAN.
Vítor Todeschini, Maximiliano S. Sangoi, Gustavo K. Goelzer, Jaison C. Machado, Clésio S. Paim, Bibiana V. Araujo, Nadia M. Volpato   +6 more
doaj   +1 more source

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

Gels, 2021
The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time.
Muhammad Suhail, Arshad Khan, Jessica M Rosenholm, Muhammad Usman Minhas, Pao-Chu Wu   +4 more
doaj   +1 more source

In Vitro Dissolution Enhancement of Felodipine

Indo Global Journal of Pharmaceutical Sciences, 2011
Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug
V P Patel, M C Gohel, null R K Parikh
openaire   +1 more source