Results 41 to 50 of about 88,172 (307)

Triboelectrification and dissolution property enhancements of solid dispersions

, 2015
The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R, Hiba Al-Hamidi (16203491), Šupuk, Enes, Conway, Barbara R., Kofi Asare-Addo (4172488), Al-Hamidi, Hiba, Owusu-Ware, Samuel, Asare-Addo, Kofi, Samuel Owusu-Ware (16228529), Barbara R. Conway (4172491), Enes Šupuk (16228532), Nokhodchi, Ali, Ali Nokhodchi (4465915)   +12 more
core   +1 more source

Relationship between dissolution rate in vitro and absorption rate in vivo of ketamine prolonged-release tablets [PDF]

, 2023
Background and Objectives: Understanding the processes that determine the time course of drug absorption rates is of great interest. This study aims to answer the questions: (1) How well can the in vitro dissolution rate predict the in vivo input ...
Weiss, Michael
core   +1 more source

In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug

Pharmaceutics
The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan® Forte as reference and two generic ...
Isabel Gonzalez-Alvarez, Alejandro Ruiz-Picazo, Ruben Selles-Talavera, Andres Figueroa-Campos, Virginia Merino, Marival Bermejo, Marta Gonzalez-Alvarez   +6 more
doaj   +1 more source

Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers

Molecules, 2023
The search for effective systems to facilitate the release of poorly bioavailable drugs is a forefront topic for the pharmaceutical market. Materials constituted by inorganic matrices and drugs represent one of the latest research strategies in the ...
Lauretta Maggi, Valeria Friuli, Giovanna Bruni, Alessia Rinaldi, Marcella Bini   +4 more
doaj   +1 more source

Factors Affecting the in Vitro Dissolution of Cobalt Oxide [PDF]

Environmental Health Perspectives, 1992
In a recent interspecies comparison of the lung clearance of cobalt oxide (57Co3O4), differences of up to 4-fold were found in the translocation rates of 57Co to blood between seven different animal species, including man. This study investigated some factors that could influence the dissolution of this material in vitro.
C G, Collier, M J, Pearce, A, Hodgson, A, Ball   +3 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

In Vitro Dissolution Studies of Immediate Release and Extended Release Formulation using Flow-through Cell Apparatus 4. Dissolution technologies [PDF]

, 2014
The aims of this study were to evaluate the dissolution performance of solid dosage forms using the open and closed modes of the FTC Apparatus 4 under different flow rates and provide examples to demonstrate the advantages of the FTC method, in ...
Qiu, S., Wang, Ke, Li, M.
core   +1 more source

A simple method to improve the dissolution of repaglinide and exploration of its mechanism

Asian Journal of Pharmaceutical Sciences, 2014
In the present study, a simple and rapid method was developed to improve the in vitro dissolution of repaglinide, an oral antidiabetic drug, which was based on addition of meglumine in 50% (v/v) ethanol to dissolve repaglinide, and the drug dissolved in ...
Zhaolu Zhu, Tianzhi Yang, Yanan Zhao, Nannan Gao, Donglei Leng, Pingtian Ding   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source