Results 21 to 30 of about 535,121 (211)

A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis [PDF]

European Cells & Materials, 2016
New regenerative materials and approaches need to be assessed through reliable and comparable methods for rapid translation to the clinic. There is a considerable need for proven in vitro assays that are able to reduce the burden on animal testing, by ...
G Hulsart-Billström, JI Dawson, S Hofmann, R Müller, MJ Stoddart, M Alini, H Redl, A El Haj, R Brown, V Salih, J Hilborn, S Larsson, ROC Oreffo   +12 more
doaj   +1 more source

One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products

Pharmaceutics, 2021
Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of this paper is to develop an in vivo predictive dissolution method for montelukast and to check
Mercedes Prieto-Escolar, Juan J. Torrado, Covadonga Álvarez, Alejandro Ruiz-Picazo, Marta Simón-Vázquez, Carlos Govantes, Jesús Frias, Alfredo García-Arieta, Isabel Gonzalez-Alvarez, Marival Bermejo   +9 more
doaj   +1 more source

A BRIEF REVIEW ON PHARMACEUTICAL DISSOLUTION INTERLINKING THE ASPECTS OF SCIENCE AND REGULATION [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2022
Dissolution is a multistep process describes the affinity of the solute and the solvent by which a solid substance interacts among the heterogeneous phases of solute -solute, solvent-solvent, and the solute-solvent interface to yield a solution.
K Monica, Biradar Gopal Rangarao, Sayani Bhattacharyya   +2 more
doaj   +1 more source

A single-center, randomized, open-label, two-period, crossover, fasted bioequivalence study: comparing recombinant human follicle-stimulating hormone for injection (JZB30) with Gonal-f® in healthy Chinese female participants

Frontiers in Pharmacology
ObjectiveThis study aimed to evaluate the pharmacokinetic (PK) bioequivalence, safety, and immunogenicity of recombinant human follicle-stimulating hormone (rhFSH) for injection (code name: JZB30), developed by Chengdu Jingze Biopharmaceutical Co., Ltd.,
Zhuo Chen, Zhuo Chen, Zhuo Chen, Qin Yu, Qin Yu, Qin Yu, Shiyin Feng, Shiyin Feng, Shiyin Feng, Li Mo, Linrui Cai, Linrui Cai, Linrui Cai, Chunfeng Du, Chunfeng Du, Chunfeng Du, Dan Du, Dan Du, Dan Du, Qin Zou, Qin Zou, Qin Zou   +21 more
doaj   +1 more source

Analysis of Common Causes of Out-of-Specification Results in the Test for Depressor Substances

Shiyan dongwu yu bijiao yixue
According to General Chapter 1145 of Division IV in the Chinese Pharmacopoeia (2020 Edition), the test for depressor substances is a common method for drug testing.
TONG Xiyang, QUE Changtian, ZHANG Feng, ZHAO Lu, WANG Hongping   +4 more
doaj   +1 more source

No dose adjustment required for warfarin or metformin when coadministered with the novel GLP-1 receptor agonist ecnoglutide: an open-label, fixed-sequence, crossover study

Frontiers in Pharmacology
ObjectiveTo characterize the drug-drug interaction (DDI) profile of the novel, long-acting GLP-1 receptor agonist ecnoglutide (XW003) with two widely co-prescribed drugs: metformin and narrow therapeutic index agent, warfarin.MethodsIn this open-label ...
Zhuo Chen, Zhuo Chen, Zhuo Chen, Zhuo Chen, Chunfeng Du, Chunfeng Du, Chunfeng Du, Chunfeng Du, Linrui Cai, Linrui Cai, Linrui Cai, Linrui Cai, Shiyin Feng, Shiyin Feng, Shiyin Feng, Shiyin Feng, Qin Zou, Qin Zou, Qin Zou, Qin Zou, Weiyi Guo, Weiyi Guo, Weiyi Guo, Weiyi Guo, Fengshan Li, Fengshan Li, Fengshan Li, Fengshan Li, Dan Du, Dan Du, Dan Du, Dan Du, Feng Hu, Feng Hu, Feng Hu, Feng Hu, Xiaohong Liu, Xiaohong Liu, Xiaohong Liu, Xiaohong Liu, Yalin Huang, Yalin Huang, Yalin Huang, Yalin Huang, Shuxia Shi, Shuxia Shi, Shuxia Shi, Shuxia Shi, Wei Shi, Wei Shi, Wei Shi, Wei Shi, Qin Yu, Qin Yu, Qin Yu, Qin Yu, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lei Guan, Liu Yang, Yao Li, Rui Liu, Jing Ning, Ming Yang, Qing Zheng   +67 more
doaj   +1 more source

In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT

Particle and Fibre Toxicology, 2021
Background Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety.
Emilio Di Ianni, Johanna Samulin Erdem, Peter Møller, Nicklas Mønster Sahlgren, Sarah Søs Poulsen, Kristina Bram Knudsen, Shan Zienolddiny, Anne Thoustrup Saber, Håkan Wallin, Ulla Vogel, Nicklas Raun Jacobsen   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source