Results 21 to 30 of about 8,610,712 (380)

Lipid droplets in granulosa cells are correlated with reduced pregnancy rates

Journal of Ovarian Research, 2020
Background Lipids are an important source for energy production during oocyte maturation. The accumulation of intracellular lipids binds to proteins to form lipid droplets. This may lead to cellular lipotoxicity. The impact of lipotoxicity on cumulus and
Shira Raviv, Shay Hantisteanu, Shilhav Meisel Sharon, Yuval Atzmon, Mediea Michaeli, Einat Shalom-Paz   +5 more
doaj   +1 more source

Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery

Cells, 2022
Background and aims: Non-alcoholic steatohepatitis (NASH) is a life-threatening stage of non-alcoholic fatty liver disease (NAFLD) for which no drugs have been approved.
Joost Boeckmans, Alexandra Gatzios, Anja Heymans, Matthias Rombaut, Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Robim M. Rodrigues   +7 more
doaj   +1 more source

In-vitro gastrointestinal digestion of kenaf seed oil-in-water nanoemulsions [PDF]

, 2016
The high nutrition value of kenaf seed oil has good potential to be used as functional foods or nutraceutical products. Kenaf seed oil-in-water nanoemulsions stabilised by ternary emulsifier mixtures, namely sodium caseinate, gum Arabic and Tween 20 were
Cheong, Ai Mun, Nyam, Kar Lin, Tan, Chin Ping   +2 more
core   +1 more source

A standardised static in vitro digestion method suitable for food - an international consensus.

Food & Function, 2014
Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable.
M. Minekus, M. Alminger, P. Alvito, S. Ballance, T. Bohn, C. Bourlieu, C. Bourlieu, F. Carrière, R. Boutrou, R. Boutrou, M. Corredig, D. Dupont, D. Dupont, C. Dufour, L. Egger, M. Golding, S. Karakaya, B. Kirkhus, S. Feunteun, U. Lesmes, A. Macierzanka, A. Mackie, S. Marze, D. Mcclements, O. Ménard, O. Ménard, I. Recio, C. Santos, Rajat Singh, G. Vegarud, M. Wickham, W. Weitschies, A. Brodkorb   +32 more
semanticscholar   +1 more source

INFOGEST static in vitro simulation of gastrointestinal food digestion

Nature Protocols, 2019
Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract.
A. Brodkorb, L. Egger, M. Alminger, P. Alvito, R. Assunção, S. Ballance, T. Bohn, C. Bourlieu-Lacanal, R. Boutrou, F. Carrière, A. Clemente, M. Corredig, D. Dupont, C. Dufour, C. Edwards, M. Golding, S. Karakaya, B. Kirkhus, S. Le Feunteun, U. Lesmes, A. Macierzanka, A. Mackie, C. Martins, S. Marze, D. Mcclements, O. Ménard, M. Minekus, R. Portmann, C. N. Santos, I. Souchon, R. P. Singh, G. Vegarud, M. Wickham, W. Weitschies, I. Recio   +34 more
semanticscholar   +1 more source

Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America, 2000
Dentinal repair in the postnatal organism occurs through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as yet undefined precursor population associated with pulp tissue.
S. Gronthos, M. Mankani, J. Brahim, P. Robey, S. Shi   +4 more
semanticscholar   +1 more source

Mate genetic similarity affects mating behaviour but not maternal investment in mice

Scientific Reports, 2023
Maternal investment can affect the survival and development of offspring. Here we experimentally investigated in mice, whether females alter implantation rates and pup survival after embryo transfer depending on the genetic similarity with their ...
Kerstin E. Auer, Jasmin Primus, Sonja Istel, Maik Dahlhoff, Thomas Rülicke   +4 more
doaj   +1 more source

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

eLife, 2022
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (GoF ...
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield   +49 more
doaj   +1 more source

Establishment and application of national reference panels for SARS-CoV-2 antigen detection kit

Biosafety and Health, 2023
To develop a national reference panel for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen detection kit and establish a quality standard. The cultures of SARS-CoV-2 and other pathogens were collected to establish a national reference
Tingting Ma, Donglai Liu, Keliang Lyu, Tingting Gao, Dawei Shi, Lanqing Zhao, Shu Shen, Yabin Tian, Sihong Xu, Haiwei Zhou   +9 more
doaj  

A robust bacterial high-throughput screening system to evaluate single nucleotide polymorphisms of human homogentisate 1,2-dioxygenase in the context of alkaptonuria

Scientific Reports, 2022
Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway.
Sien Lequeue, Jessie Neuckermans, Ine Nulmans, Ulrich Schwaneberg, Tamara Vanhaecke, Joery De Kock   +5 more
doaj   +1 more source