Results 31 to 40 of about 8,610,712 (380)

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Cells, 2022
Astrocytes (ACs) do not only play a role in normal neurogenesis and brain homeostasis, but also in inflammatory and neurodevelopmental disorders. We studied here the different patterns of inflammatory activation triggered by cytokines in human induced ...
Anna-Sophie Spreng, Markus Brüll, Heidrun Leisner, Ilinca Suciu, Marcel Leist   +4 more
doaj   +1 more source

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries

mAbs, 2021
Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging.
Pallavi Bhatta, Kevin D. Whale, Amy K. Sawtell, Clare L. Thompson, Stephen E. Rapecki, David A. Cook, Breda M. Twomey, Milena Mennecozzi, Laura E. Starkie, Emily M. C. Barry, Shirley J. Peters, Ahmad M. Kamal, Helene M. Finney   +12 more
doaj   +1 more source

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro

Frontiers in Immunology, 2020
Neutrophils act as the first line of defense against invading pathogens. Although traditionally considered in context of their antimicrobial effector functions, the importance of tumor-associated neutrophils (TANs) in the development of cancer has become
Mareike Ohms, Sonja Möller, T. Laskay
semanticscholar   +1 more source

Performance of In Vitro Cassava (Manihot esculenta Crantz) Plantlets Weaned with Locally Sourced Substrates [PDF]

, 2018
The performance of in vitro cassava plantlets weaned on different locally sourced substrates was evaluated. Nodal cuttings were excised from healthy six weeks old OG 001cassava variety in the culture room of tissue culture laboratory of National Root ...
Iwuagwu, M. O. (Mary), Nwosu, N. N. (Nancy)   +1 more
core   +1 more source

Diagnosing ventilator-associated pneumonia (VAP) in UK NHS ICUs: the perceived value and role of a novel optical technology

Diagnostic and Prognostic Research, 2022
Background Diagnosing ventilator-associated pneumonia (VAP) in an intensive care unit (ICU) is a complex process. Our aim was to collect, evaluate and represent the information relating to current clinical practice for the diagnosis of VAP in UK NHS ICUs,
W. S. Jones, J. Suklan, A. Winter, K. Green, T. Craven, A. Bruce, J. Mair, K. Dhaliwal, T. Walsh, A. J. Simpson, S. Graziadio, A. J. Allen   +11 more
doaj   +1 more source

An In Vitro Microneutralization Assay for SARS‐CoV‐2 Serology and Drug Screening

Current Protocols in Microbiology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged in the city of Wuhan, Hubei Province, China, in late 2019. Since then, the virus has spread globally and caused a pandemic.
F. Amanat, K. White, Lisa Miorin, Shirin Strohmeier, Meagan McMahon, Philip Meade, Wen-Chun Liu, R. Albrecht, V. Simon, L. Martínez-Sobrido, T. Moran, A. García-Sastre, F. Krammer   +12 more
semanticscholar   +1 more source

Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods.

Comprehensive Reviews in Food Science and Food Safety, 2020
Oral bioavailability is the key to the bioefficiency of food bioactive ingredients; it evaluates the relationship between foods and their health benefits.
C. Dima, E. Assadpour, S. Dima, S. Jafari   +3 more
semanticscholar   +1 more source

Proximate analysis and in-vitro gas production of predominant forages in Afe Babalola University rangeland as feed resources for ruminant production [PDF]

, 2017
In Nigeria, the major feed resource for ruminant production is the natural grazeland. However, most forage found on such lands cannot absolutely support ruminant production.
Bamigboye, F. O. (F), Oluwarinde, O. (O)
core   +1 more source

Identification of two early blood biomarkers ACHE and CLEC12A for improved risk stratification of critically ill COVID-19 patients

Scientific Reports, 2023
In order to identify biomarkers for earlier prediction of COVID-19 outcome, we collected blood samples from patients with fatal outcomes (non-survivors) and with positive clinical outcomes (survivors) at ICU admission and after seven days.
Simone Kattner, Jan Müller, Karolina Glanz, Mehdi Manoochehri, Caroline Sylvester, Yevhen Vainshtein, Marc Moritz Berger, Thorsten Brenner, Kai Sohn   +8 more
doaj   +1 more source