Results 21 to 30 of about 549,804 (200)
Frontiers in Pharmacology, 2023 Background: Tuberculosis continues to be a significant global burden. Purified protein derivative of tuberculin (TB-PPD) is one type of tuberculin skin test (TST) and is used commonly for the auxiliary diagnosis of tuberculosis.
Sha Diao +50 more
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Frontiers in Public Health, 2023 ObjectivesRecombinant Mycobacterium tuberculosis fusion protein (EC) was anticipated to be used for the scale-up of clinical application for diagnosis of Mycobacterium tuberculosis infection in China, but it lacked a head-to-head economic evaluation ...
Zheng Liu +50 more
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Accessibility of essential anticancer medicines for children in the Sichuan Province of China
Frontiers in Public Health, 2022 BackgroundCompared with high-income countries, the survival rate of childhood cancer is lower in low- and middle-income countries. Access to essential anticancer medicines is an indispensable component of pediatric cancer treatment, which is still a big ...
Zhe Chen +35 more
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Effectiveness and safety of Lacosamide therapy for children with focal epilepsy: a real world study
Frontiers in Pharmacology, 2023 Objectives: To compare the effectiveness and safety of the new antiepileptic drug, lacosamide (LCM) with Levetiracetam, for the treatment of focal epilepsy in children.Methods: This study was a cohort study.
Chunsong Yang +16 more
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Frontiers in Pharmacology, 2021 Due to its very low water solubility and complex pharmacokinetics, a reliable point-to-point correlation of its in vitro release with its pharmacokinetics has not been achieved so far with amiodarone. The correlation of the in vitro dissolution of a drug
Maytham Razaq Shleghm +4 more
doaj +1 more source
In vitro–In Vivo Correlations: Tricks and Traps [PDF]
The AAPS Journal, 2012 In vitro-in vivo correlation (IVIVC) is a biopharmaceutical tool recommended to be used in development of formulation. When validated, it can speed up development of formulation, be used to fix dissolution limits and also as surrogate of in vivo study. However, as do all tools, it presents limitations and traps.
J-M, Cardot, B M, Davit
openaire +2 more sources
In vitro and in vivo antischistosomal activity of ferroquine derivatives [PDF]
, 2014 Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development.
Riccardo Rubbiani +9 more
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Pharmaceutics, 2021 Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of this paper is to develop an in vivo predictive dissolution method for montelukast and to check
Mercedes Prieto-Escolar +9 more
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A BRIEF REVIEW ON PHARMACEUTICAL DISSOLUTION INTERLINKING THE ASPECTS OF SCIENCE AND REGULATION [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 Dissolution is a multistep process describes the affinity of the solute and the solvent by which a solid substance interacts among the heterogeneous phases of solute -solute, solvent-solvent, and the solute-solvent interface to yield a solution.
K Monica +2 more
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In vitro-in vivo correlation from lactide-co-glycolide polymeric dosage forms. [PDF]
Prog Biomater, 2014 The objective of this study was to compare the in vitro behavior of four long-acting subcutaneous ris- peridone formulations with in vivo performance, with the intent of establishing an IVIVC. Two copolymers of PLGA (50:50 and 75:25) were used to prepare
D'Souza S +3 more
europepmc +2 more sources