Results 41 to 50 of about 549,804 (200)

In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT

Particle and Fibre Toxicology, 2021
Background Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety.
Emilio Di Ianni, Johanna Samulin Erdem, Peter Møller, Nicklas Mønster Sahlgren, Sarah Søs Poulsen, Kristina Bram Knudsen, Shan Zienolddiny, Anne Thoustrup Saber, Håkan Wallin, Ulla Vogel, Nicklas Raun Jacobsen   +10 more
doaj   +1 more source

Hepatic intracellular free drug concentration and unbound partition coefficient: development and validation of an in vitro methodology to predict in vivo liver drug exposure

, 2023
reservedThe Free drug hypothesis states that only the unbound drug molecules are able, in the site of action, to interact with the target and exert the pharmacodynamic effect.
FONTANA, NICCOLÒ
core  

Correlation between in vitro and in vivo activity of levofloxacin and moxifloxacin against pneumococcal strains with different susceptibilities to fluoroquinolones

, 2006
In vitro and in vivo models were developed to evaluate the efficacy of levofloxacin and moxifloxacin against three serotype 3 pneumococcal strains with different susceptibilities to fluoroquinolones (wild-type, parC mutant, and parC, parE and gyrA mutant)
Gracia, Matilde, Alou Cervera, Luis, Martínez-Marín, Carmina, Huelves, Lorena, Prieto Prieto, José, Ponte, María del Carmen, Sevillano Fernández, David, López-Casla, María Teresa, Soriano, Francisco   +8 more
core   +1 more source

Advances on cancer vaccine trials registered in China and the USA in 2014-2024

Frontiers in Oncology
ObjectiveThe clinical trials of cancer vaccine in China and the USA were summarized and compared over the past decade, thus putting forward suggestions for future clinical development in this field.MethodsMainly based on the Centre for Drug Evaluation of
Wei Shi, Wei Shi, Wei Shi, Wei Shi, Zhuo Chen, Zhuo Chen, Zhuo Chen, Zhuo Chen, Qin Yu, Qin Yu, Qin Yu, Qin Yu, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang   +17 more
doaj   +1 more source

Preparation of Colon-Targeted Acetylharpagide Tablets and its Release Properties in vivo and in vitro

Frontiers in Pharmacology, 2018
Ethno Pharmacological Relevance: Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases in Southern China.Aim of the Study: The present study designed and investigated the ...
DeWen Liu, Huijie Yan, Yiming Kong, Yun You, Yanling Li, Lixin Wang, Yan Tong, Jinyu Wang   +7 more
doaj   +1 more source

Dermal Delivery of Niacinamide—In Vivo Studies

Pharmaceutics, 2021
In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In
Yanling Zhang, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, Majella E. Lane   +5 more
doaj   +1 more source

Analysis of clinical research coordinator (CRC) deviation from assigned responsibilities in Sichuan, China based on empirical investigation

Frontiers in Medicine
ObjectiveExploring the current status and causes of overstepping behavior among clinical research coordinators: providing reference for standardizing CRC responsibilities and safeguarding clinical trial quality and subject safety.MethodsThe research ...
Shuxia Shi, Shuxia Shi, Shuxia Shi, Shuxia Shi, Shangyuan Qin, Qin Yu, Qin Yu, Qin Yu, Qin Yu   +8 more
doaj   +1 more source

Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Pharmaceutics, 2023
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska, Tomasz Pietrzak   +6 more
doaj   +1 more source

Avaliação toxicológica de nanopartículas compostas de dióxido de titânio, superparamagnéticas de óxido de ferro e de poliuretano in vitro, in vivo, ex vivo e in silico [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A nanotecnologia envolve a compreensão e manipulação da matéria em escala nanométrica, em que os ...
Silva, Adny Henrique
core  

Dissolution method for delapril and manidipine combination tablets based on an absorption profile of manidipine

Journal of Pharmaceutical Analysis, 2016
The present study describes the development and validation of a dissolution method for delapril (DEL) and manidipine (MAN) combination tablets, using a simulated absorption profile based on in vivo data for MAN.
Vítor Todeschini, Maximiliano S. Sangoi, Gustavo K. Goelzer, Jaison C. Machado, Clésio S. Paim, Bibiana V. Araujo, Nadia M. Volpato   +6 more
doaj   +1 more source