Results 31 to 40 of about 549,804 (200)

In vitro - In vivo correlation of gene expression alterations induced by liver carcinogens [PDF]

, 2012
Although cultivated hepatocytes are widely used in the studies of drug metabolism, their application in toxicogenomics is considered as problematic, because previous studies have reported only little overlap between chemically induced gene expression ...
Guenther, G., Hellwig, B., Oberemm, A., Heise, T., Godoy, P., Schug, M., Mielke, H., Storm, D., Rahnenführer, J., Gundert-Remy, U., Ahr, H.J., Ghallab, A., Lampen, A., Reif, R., G. Hengstler, J., Hengstler, J.G., J. Ahr, H., Ellinger-Ziegelbauer, H., Sisnaiske, J.   +18 more
core   +1 more source

An in vitro comparison between two methods of electrical resistance measurement for occlusal caries detection [PDF]

, 2006
Because of different measurement techniques and the easier design of the CRM prototype, this in vitro study aimed to compare the diagnostic performance and reproducibility of two electrical methods (Electronic Caries Monitor III, ECM and Cariometer 800 ...
Stosser, L., Huysmans, MCDNJM, Heinrich-Weltzien, Roswitha, Kühnisch, Jan, Tabatabaie, M., Tabatabaie, M, Huysmans, Marie-Charlotte D. N. J. M., Kuhnisch, J, Heinrich-Weltzien, R, Stosser, L   +9 more
core   +1 more source

A single-center, randomized, open-label, two-period, crossover, fasted bioequivalence study: comparing recombinant human follicle-stimulating hormone for injection (JZB30) with Gonal-f® in healthy Chinese female participants

Frontiers in Pharmacology
ObjectiveThis study aimed to evaluate the pharmacokinetic (PK) bioequivalence, safety, and immunogenicity of recombinant human follicle-stimulating hormone (rhFSH) for injection (code name: JZB30), developed by Chengdu Jingze Biopharmaceutical Co., Ltd.,
Zhuo Chen, Zhuo Chen, Zhuo Chen, Qin Yu, Qin Yu, Qin Yu, Shiyin Feng, Shiyin Feng, Shiyin Feng, Li Mo, Linrui Cai, Linrui Cai, Linrui Cai, Chunfeng Du, Chunfeng Du, Chunfeng Du, Dan Du, Dan Du, Dan Du, Qin Zou, Qin Zou, Qin Zou   +21 more
doaj   +1 more source

Analysis of Common Causes of Out-of-Specification Results in the Test for Depressor Substances

Shiyan dongwu yu bijiao yixue
According to General Chapter 1145 of Division IV in the Chinese Pharmacopoeia (2020 Edition), the test for depressor substances is a common method for drug testing.
TONG Xiyang, QUE Changtian, ZHANG Feng, ZHAO Lu, WANG Hongping   +4 more
doaj   +1 more source

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]

, 2013
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
Vodovotz, Yoram, Derek Barclay, Ruben Zamora, Zamora, R, Bartels John, Billiar, TR, Yoram Vodovotz (59974), Billiar Timothy R., Rami A Namas, Vodovotz, Y, Derek Barclay (258485), Bartels, John, Rosemary Hoffman, Rami A. Namas, Barclay, Derek, Ruben Zamora (221654), Hoffman, Rosemary, Rami A. Namas (429290), Hoffman Rosemary, Billiar, Timothy R., Rosemary Hoffman (429291), Zamora Ruben, Timothy R Billiar, Namas Rami A., Yoram Vodovotz, Barclay Derek, Namas, RA, John Bartels (377805), Timothy R. Billiar (91972), Vodovotz Yoram, John Bartels, Namas, Rami A, Timothy R. Billiar, Zamora, Ruben, Hoffman, R, Barclay, D, Bartels, J   +36 more
core   +1 more source

No dose adjustment required for warfarin or metformin when coadministered with the novel GLP-1 receptor agonist ecnoglutide: an open-label, fixed-sequence, crossover study

Frontiers in Pharmacology
ObjectiveTo characterize the drug-drug interaction (DDI) profile of the novel, long-acting GLP-1 receptor agonist ecnoglutide (XW003) with two widely co-prescribed drugs: metformin and narrow therapeutic index agent, warfarin.MethodsIn this open-label ...
Zhuo Chen, Zhuo Chen, Zhuo Chen, Zhuo Chen, Chunfeng Du, Chunfeng Du, Chunfeng Du, Chunfeng Du, Linrui Cai, Linrui Cai, Linrui Cai, Linrui Cai, Shiyin Feng, Shiyin Feng, Shiyin Feng, Shiyin Feng, Qin Zou, Qin Zou, Qin Zou, Qin Zou, Weiyi Guo, Weiyi Guo, Weiyi Guo, Weiyi Guo, Fengshan Li, Fengshan Li, Fengshan Li, Fengshan Li, Dan Du, Dan Du, Dan Du, Dan Du, Feng Hu, Feng Hu, Feng Hu, Feng Hu, Xiaohong Liu, Xiaohong Liu, Xiaohong Liu, Xiaohong Liu, Yalin Huang, Yalin Huang, Yalin Huang, Yalin Huang, Shuxia Shi, Shuxia Shi, Shuxia Shi, Shuxia Shi, Wei Shi, Wei Shi, Wei Shi, Wei Shi, Qin Yu, Qin Yu, Qin Yu, Qin Yu, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lei Guan, Liu Yang, Yao Li, Rui Liu, Jing Ning, Ming Yang, Qing Zheng   +67 more
doaj   +1 more source

Estimation of human blood LC50 values for use in modeling of in vitro – in vivo data of the ACuteTox project

, 2008
The main aim of the ACuteTox project, under EU 6th Framework programme, is to investigate whether animal toxicity tests for acute systemic toxicity could be replaced by a combination of alternative assays. Data for 97 reference chemicals was collected in
Clothier, Richard, Sjöström, Michael,, Clemedson, Cecilia, Kolman, Ada   +3 more
core   +1 more source

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers [PDF]

, 2010
Background: High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification.
B Bell, Griffiths, John R, Griffiths John R, Fellows, G.A., Wilson, M, Bell, B Anthony, Wright, Alan J, Wilson M, Fellows, Greg A, Howe, F.A., Bell, B.A., John R Griffiths, Wright, AJ, Wright Alan J, Fellows Greg A, Bell, BA, Bell B, Franklyn A Howe, Alan J Wright, Griffiths, JR, Greg A Fellows, Wright, A.J., Wilson, Martin; id_orcid, Griffiths, J.R., Wilson, M., Fellows, GA, Howe, FA, Howe Franklyn A, Howe, Franklyn A, M Wilson   +29 more
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Electrophysiological correlates of hyperalgesic priming in vitro and in vivo [PDF]

Pain, 2013
We have modeled the transition from acute to chronic pain in the rat. In this model (termed hyperalgesic priming) a chronic state develops after a prior inflammatory process or exposure to an inflammatory mediator, in which response to subsequent exposure to prostaglandin E2 (PGE2) is characterized by a protein kinase Cε-dependent marked prolongation ...
Hendrich, Jan, Alvarez, Pedro, Joseph, Elizabeth K, Chen, Xiaojie, Bogen, Oliver, Levine, Jon D   +5 more
openaire   +4 more sources

Dehydration of hydrogen contact lenses in vitro and in vivo

, 1988
An attempt was made to derive a model for predicting the extent of hydrogel lens dehydration in vivo (delta Wv) by using a contact lens refractometer to (1) measure the water content (W) of eight lenses ranging from 36.5 to 85.8% water before and after ...
Graeme Young, Nathan Efron, Efron, Nathan, Young, Graeme   +3 more
core   +1 more source