Results 61 to 70 of about 549,804 (200)

An in-vivo - in-vitro correlation for the bioavailability of frusemide tablets

Journal of Pharmacy and Pharmacology, 1984
The dissolution behaviour of four commercial and two experimental formulations of frusemide tablets has been investigated using the USP rotating basket apparatus and pH 5.0 buffer at 37 degrees C as the test medium. There is a linear relationship between the percentage dissolution in 30 min and the bioavailability relative to an oral solution of ...
M, Kingsford, N J, Eggers, G, Soteros, T J, Maling, R J, Shirkey   +4 more
openaire   +2 more sources

Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo [PDF]

, 2010
Linear poly(amidoamine)s (PAAs) have been designed to exhibit minimal non-specific toxicity, display pH-dependent membrane lysis and deliver genes and toxins in vitro.
Nathalie Lavignac, R. Duncan, Richardson, Simon C.W., Duncan, Ruth, P. Ferruti, S. C. W. Richardson, N. Lavignac, N. G. Pattrick, Nicola G. Pattrick, Paolo Ferruti, Simon C.W. Richardson, Pattrick, Nicola G., Ferruti, Paolo, Lavignac, Nathalie, Richardson, Simon C. W., Ruth Duncan   +15 more
core   +1 more source

Correlation between the results of in vitro and in vivo chromosomal damage tests in consideration of exposure levels of test chemicals

Genes and Environment, 2018
Introduction We examined the correlation between the results of in vitro and in vivo chromosomal damage tests by using in-house data of 18 pharmaceutical candidates that showed positive results in the in vitro chromosomal aberration or micronucleus test ...
Eiji Yamamura, Chinami Aruga, Shigeharu Muto, Nobuyuki Baba, Yoshifumi Uno   +4 more
doaj   +1 more source

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging [PDF]

, 2017
Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer´s disease.
Windhorst, Albert D., van Waarde, Aren, Gert Luurtsema, Renske M. Raaphorst, Windhorst, A.D., Savolainen, H., Cantore, M., Albert Windhorst, Steeg, E. van de, Heli Savolainen, van de Steeg, Evita, Lammertsma, Adriaan A., Albert D. Windhorst, Cantore, Mariangela, Nicola A. Colabufo, Luurtsema, Geert, Elsinga, P.H., Raaphorst, R.M., Colabufo, N.A., Savolainen, Heli, Colabufo, Nicola A., Renske Raaphorst, Evita van de Steeg, Philip H. Elsinga, Elsinga, Philip H., van Waarde, Aren; id_orcid, Lammertsma, A.A., Adriaan Lammertsma, Raaphorst, Renske M., Luurtsema, G., Nicola Colabufo, Adriaan A. Lammertsma, Waarde, A. van, Luurtsema, Gert, Philip Elsinga, Mariangela Cantore, Aren van Waarde   +36 more
core   +1 more source

Comparative in vitro-in vivo correlation analysis with pioglitazone tablets

, 2022
Objective: To assess the in vitro. in vivo correlation of immediate release formulation of pioglitazone 30 mg film coated tablet. Methods: In vitro release data were obtained for test and reference formulation using the USP paddle method (Apparatus 2) at
Sajal Kumar Saha (13092990), A K A Chowdhury (13362834), S C Das (13362822), S C Bachar (13362801), M A Uddin (13362831), R H Kuddus (13362837)   +5 more
core  

An overview of the alarming impediments encountered while establishing an apposite IVIVC of nanomedicines necessitated its regulatory approval

OpenNano
For the past three decades, the principle of nanotechnology has been widely employed to develop pharmaceuticals and bio-pharmaceuticals that are successful for many disease therapies.
Nandakumar Selvasudha, Joseph Pushpa Sweety, Gover Antoniraj M, Kandasamy Ruckmani   +3 more
doaj   +1 more source

Brain targeted delivery of paclitaxel using endogenous ligand

Asian Journal of Pharmaceutical Sciences, 2016
The objective of the present investigation was to formulate nanoparticles constructed using PLGA polymer for the effective targeted delivery to brain via nasal route.
Sanjeev R. Acharya, Padmanabha R.V. Reddy   +1 more
doaj   +1 more source

Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

Pharmaceutics, 2020
This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution.
Dong-Seok Lee, Dong Wook Kang, Go-Wun Choi, Han-Gon Choi, Hea-Young Cho   +4 more
doaj   +1 more source

Neuronal in vitro models for the estimation of acute systemic toxicity.

, 2009
The objective of the EU funded integrated project "ACuteTox" is to develop a strategy in which general cytotoxicity, together with organ-specific endpoints and biokinetic features, are taken into consideration in the in vitro prediction of oral acute ...
Honegger, P., Gustafsson, H., Pallas, M., Rimbau, V., Zurich, M.G., Suñol, C., Coecke, S., Forsby, A., Vericat, J.A., Camins, A., Kinsner-Ovaskainen, A., Bal-Price, A.K., Fabre, N., Rodríguez-Farré, E.   +13 more
core   +1 more source

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

, 2012
Michael F Wempe,1 Janet W Lightner,2 Bettina Miller,1 Timothy J Iwen,1 Peter J Rice,1 Shin Wakui,3 Naohiko Anzai,4 Promsuk Jutabha,4 Hitoshi Endou51Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Anschutz Medical
Wempe MF, Endou H, Jutabha P, Iwen TJ, Wakui S, Lightner JW, Rice PJ, Anzai N, Miller B   +8 more
core