Results 81 to 90 of about 549,804 (200)

High-selective hepatic removel of deoxyschizandrin in microsomes in vitro and correlation with perfusion data

, 2010
Aim to develop deoxyschizandrin (DS), one of the major active lignans isolated from Schisandra fruits, as a novel high-selective in vivo CYP3A probe. We investigated the respective contributions of enzyme and transporter to hepatic clearance in vitro and
Ling Yang, 吴敬敬
core  

In Vitro Evaluation of Poly(D,L-lactide-co-glycolide) In Situ Gels and Pharmacokinetics Following Subcutaneous Injection in Rats for Model Drugs

Pharmaceutics
Background/Objectives. This research supports the development of long-acting injectables (LAIs) via in situ gel (ISG) technology by illustrating the influence of drug properties and formulation variables on in vitro drug release (Part 1), and providing ...
Sandy Van Hemelryck, Charlotte Vercammen, Eline Seldeslachts, Koen Wuyts, Ils Pijpers, René Holm, Erik Mannaert, Peter Langguth   +7 more
doaj   +1 more source

Minimum Antibiotic Levels for Selecting a Resistance Plasmid in a Gnotobiotic Animal Model [PDF]

, 1989
The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree rates colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid.
Lumeau, Solange, Corpet, Denis E., Corpet, Florence   +2 more
core  

In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

, 2009
Oral administration is the most common route for drug administration. However, after oral administration, the absorption may be erratic and incomplete.
del Amo, Eva M., Heikkinen, Aki T., Mönkkönen, Jukka   +2 more
core   +1 more source

In Vitro – In Vivo Correlation of Pentoxifylline: A Comprehensive Kinetic Analysis

Studia Universitatis Babes-Bolyai Chemia
This study presents an analysis of In Vitro-In Vivo Correlation (IVIVC) for pentoxifylline modified-release tablets, with a focus on deriving robust predictive models.
Maria CODREANU, Diana IACOB, Maria Ioana ONOFREI, Ana-Maria VLASE, Dana Maria MUNTEAN, Laurian VLASE   +5 more
doaj   +1 more source

Establishment of a rat hepatic in vitro system that provides a good in vitro-in vivo correlation of carcinogen-induced gene expression alterations

, 2009
At present, toxicogenomics for predictive toxicology is mostly used in vivo in order to obtain comprehensive information about the involved mode and mechanism of action of toxicants.
Schug,M., Oberemm,A., Heise,T., Lampen,A., Hengstler,J.G., Storm,D., Günter,G.   +6 more
core  

In vitro release and in vitro–in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles

International Journal of Nanomedicine, 2012
Xia Cao*, Wen-Wen Deng*, Min Fu*, Liang Wang, Shan-Shan Tong, Ya-Wei Wei, Ying Xu, Wei-Yan Su, Xi-Ming Xu, Jiang-Nan YuDepartment of Pharmaceutics, School of Pharmacy, and Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University ...
Cao X, Deng WW, Fu M, Wang L, Tong SS, Wei YW, Xu Y, Su WY, Xu XM, Yu JN   +8 more
doaj  

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines

Nano TransMed
Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles,
Ugochi E. Ewii, Anthony A. Attama, Emmanuel O. Olorunsola, Adaeze Linda Onugwu, Fortune Uchechukwu Nwakpa, Chioma Anyiam, Chinonye Chijioke, Toochukwu Ogbulie   +7 more
doaj   +1 more source

Development and In Vitro-In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease. [PDF]

Int J Mol Sci, 2023
Zhang C, Shao H, Han Z, Liu B, Feng J, Zhang J, Zhang W, Zhang K, Yang Q, Wu S.   +9 more
europepmc   +1 more source

Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology

, 2006
OBJECTIVES: The goal of the present study was to compare the accuracy of in vivo tissue characterization obtained by intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, known as Virtual Histology (VH), to the in vitro histopathology of ...
Terashima, Mitsuyasu, Matsubara, Tetsuo, Surmely, Jean-François, Ehara, Mariko, Virmani, Renu, Katoh, Osamu, Suzuki, Takahiko, Ito, Tatsuya, Tsuchikane, Etsuo, Vince, D Geoffrey, Nasu, Kenya, Vince, D. Geoffrey, Takeda, Yoshihiro, Murata, Akira   +13 more
core   +1 more source