Results 111 to 120 of about 114,426,039 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Influence of the Culture Medium on In Vitro Meiotic Competence of Canine Oocytes
Scientific Papers Animal Science and Biotechnologies, 2023 Although in carnivores modern breeding biotechnologies have developed particularly over the last 15 years, studies in the bitch oocytes are less than in other species due to the reduced availability of biological material.
Ioana Hașegan +4 more
doaj
Determination of non-invasive viability markers for human embryos in in vitro fertilization. [PDF]
, 2010 The major challenge currently facing human in vitro fertilization (IVF) programs is the prevention of multiple gestation pregnancies. The replacement of multiple embryos to fertility patients is common practice to increase pregnancy rates.
Feil, Deanne Kate
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Tingkat Maturasi in vitro Oosit Kambing dalam Medium dengan Suplementasi Serum dan Albumin
Jurnal Veteriner, 2009 The present study aimed to study the effect of ?maturation media? on maturation rate of goat oocytesafter in vitro maturation. Goat ovaries were collected from a slaughter house in Godean, Sleman.
Sri Gustari +4 more
doaj
Clinical procedures for in vitro maturation treatment
Fertility and SterilityTo demonstrate clinical techniques for in vitro maturation (IVM) treatment, including stimulation recommendations, small follicle pick-up procedures, and compact cumulus-oocyte complex (COC) search practice.This video utilizes live-action footage from surgery and embryology practice for a representative IVM treatment cycle, with step-by-step ...
Michel De Vos +4 more
openaire +3 more sources
Details of the in vitro maturation procedure.
, 2013 Details of the in vitro maturation procedure.
Mario Mignini Renzini (375547) +8 more
core +1 more source