Results 51 to 60 of about 397,646 (312)

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Human oocyte capacitation culture: Essential step toward hormone‐free assisted reproductive technology

Reproductive Medicine and Biology
Background In vitro oocyte maturation (IVM) is not a novel concept; however, its wide‐scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Johan Smitz, Flor Sánchez, Sergio Romero, Heidi Van Ranst, Ellen Anckaert, Robert B. Gilchrist, Tuong M. Ho, Lan N. Vuong, Yoshiharu Morimoto   +8 more
doaj   +1 more source

Quercetin Efficacy on in vitro Maturation of Porcine Oocytes

Scientific Papers Animal Science and Biotechnologies, 2023
The present study proposed to examine the effects of a polyphenol (quercetin) on in vitro maturated parameters. Quercetin it has been extensively studied by researchers on animals over the 35 years.
Delia Orlovschi, Ileana Miclea, Marius Zahan, Vasile Miclea, Anamaria Pernes   +4 more
doaj  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

In vitro blastocyst development of post-thaw vitrified bovine oocytes [PDF]

Veterinary World, 2013
Aim: To evaluate the developmental competence of post-thaw vitrified bovine cumulus-oocyte complexes (COCs) in vitro.Materials and Methods: A total of 129 COCs were cryopreserved using vitrification solution comprising of 15% ethylene glycol (EG) + 15 ...
D. J. Dutta,, Hiramoni Dev, Himangshu Raj   +2 more
doaj   +1 more source

Oocyte in vitro maturation: A sytematic review

Journal of Turkish Society of Obstetric and Gynecology, 2018
In vitro maturation (IVM) is one of the most controversial aspects of assisted reproductive technology. Although it has been studied extensively, it is still not a conventional treatment option and is accepted as an alternative treatment.
Ş. Hatırnaz, B. Ata, E. Hatırnaz, M. Dahan, S. Tannus, Justin Tan, Seang Tan   +6 more
semanticscholar   +1 more source

Induction and Maturation of Hepatocyte-Like Cells In Vitro: Focus on Technological Advances and Challenges

Frontiers in Cell and Developmental Biology, 2021
Limited by the poor proliferation and restricted sources of adult hepatocytes, there is an urgent need to find substitutes for proliferation and cultivation of mature hepatocytes in vitro for use in disease treatment, drug approval, and toxicity testing.
Ye Xie, Jia Yao, Wei-lin Jin, Longfei Ren, Xun Li   +4 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM – a microarray approach

Reproductive Biology and Endocrinology, 2017
Background The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells.
Joanna Budna, Marta Rybska, Sylwia Ciesiółka, Artur Bryja, Sylwia Borys, Wiesława Kranc, Katarzyna Wojtanowicz-Markiewicz, Michal Jeseta, Ewa Sumelka, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel, Bartosz Kempisty   +15 more
doaj   +1 more source

Current State of In Vitro Embryo Production in African Lion (Panthera leo)

Animals, 2022
In the last 30–40 years, in vitro maturation (IVM) and fertilization (IVF) of domestic cat oocytes have been established as part of the panel of assisted reproduction technologies.
Jennifer Zahmel, Kim Skalborg Simonsen, Julia Stagegaard, Sergio Eliseo Palma-Vera, Katarina Jewgenow   +4 more
doaj   +1 more source