Results 71 to 80 of about 640,334 (311)

Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization

Journal of Animal Science and Biotechnology, 2022
Background Heavy metal cadmium (Cd) is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility.
Anna Rita Piras, Federica Ariu, Alessio Maltana, Giovanni Giuseppe Leoni, Nicola Antonio Martino, Antonella Mastrorocco, Maria Elena Dell’Aquila, Luisa Bogliolo   +7 more
doaj   +1 more source

In vitro maturation of germinal vesicle oocytes in stimulated intracytoplasmic sperm injection cycles [PDF]

, 2011
Objective: This study evaluated in vitro maturation (IVM) of oocytes in the germinal vesicle (GV) stage in stimulated intracytoplasmic sperm injection (ICSI) cycles.
Esmaelzadeh, S., Farsi, M.M., Golalipour, M.J., Jorsaraei, S.G.A.   +3 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mitochondria directly influence fertilisation outcome in the pig [PDF]

, 2006
The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome.
Abeydeera, Alves, Anderson, Barritt, Barritt, Barritt, Blok, Brenner, Cetica, Clayton, Cohen, Cohen, Cran, de Loos, Downs, Dumollard, Eisen, Emma C Spikings, Findlay, Fong, Hue, Jansen, Justin C St John, King, Koo, Krakauer, Larsson, Larsson, Li, Lin, Liu, Mach  ty, Marchington, Mariana Freitas, Marinos, McConnell, Michaels, Moyes, Park, Pik  , Poulton, Raghu, Reynier, Roca, Sathananthan, Shahinaz H El Shourbagy, Shea, Spelbrink, St John, St John, St John, St John, St. John, Stojkovic, Sun, Tessa, Tian, Trimarchi, Ursing, Van Blerkom, Van Blerkom, Van Blerkom, Wakayama, Wallace, Wilmut, Zamzami, Zernicka-Goetz   +66 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Human in vitro models for understanding mechanisms of autism spectrum disorder. [PDF]

, 2020
Early brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental ...
Geschwind, Daniel H, Gordon, Aaron
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cortisol prevents the suppressive effect of LPS on bovine oocyte maturation in vitro

The Journal of Reproduction and Development
During the periovulatory period, local production of cortisol surges in the bovine cumulus-oocyte complex (COC), although its physiological significance is not well understood.
Sameera PREMARATNE, Mahiro TAMURA, Omowumi ADEMOLA, Yuki MURANISHI, Masafumi TETSUKA   +4 more
doaj   +1 more source