Results 81 to 90 of about 114,426,039 (308)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Altered cytoplasmic maturation in rescued in vitro matured oocytes

Human Reproduction, 2019
Do culture conditions affect cytoplasmic maturation in denuded immature non-GV oocytes?The maturation rate of denuded non-GV oocytes is not affected by culture media, but in vitro maturation seems to alter the mitochondrial membrane potential, endoplasmic reticulum (ER) and actin cytoskeleton compared with in vivo maturation.In vitro maturation of ...
A, Ferrer-Vaquer, M, Barragán, A, Rodríguez, R, Vassena   +3 more
openaire   +2 more sources

Temporal progression in migratory status and sexual maturation in European silver eels during downstream migration [PDF]

, 2011
The onset of downstream migration of European eels is accompanied by a cessation of feeding and the start of sexual maturation which stresses the link between metabolism and sexual maturation, also suggesting an important role for exercise.
Guerrero, M.A., Gerard de Laak, Thillart, G.E.E.J.M., Ma. Angeles Guerrero, Guido E. E. J. M. van den Thillart, Arjan P. Palstra, Jan P. G. Klein Breteler, Palstra, A.P., Klein Breteler, J.G.P.   +8 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Perbandingan Morfologi Antara Oosit Sapi yang di Vitrifikasi Sebelum dan Sesudah Maturasi In Vitro = The Comparison of Morphology Between Bovine Oocyte Vitrification Before and After In Vitro Maturation

, 2014
Vitrification method has become a growing and promising technology in assisted reproductive technology. Freezing embryos are more common, freezing oocytes are longer growing because the physical characteristics of oocyte.
Faizah, Zakiyatul, Hinting, Aucky, Widjiati, Darsini, Ninik   +3 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

FERTILIZACION DE OVOCITOS CAPRINOS MADURADOS EN DOS MEDIOS DE CULTIVO

Tropical and Subtropical Agroecosystems, 2010
El objetivo del estudio fue evaluar el efecto de dos medios de cultivo en la tasa de maduración y fertilización de ovocitos de cabra. Los complejos cumulus ovocito (CCO´s) fueron obtenidos de ovarios de cabras post-mortem. En el experimento I (EXP I),
Alejandra Soberano Martinez, A. Bravo, I. Olivo, I. Toscano, M. Cajero, J. Herrera, M. Navarro, J. Segura   +7 more
doaj  

Cortisol prevents the suppressive effect of LPS on bovine oocyte maturation in vitro

The Journal of Reproduction and Development
During the periovulatory period, local production of cortisol surges in the bovine cumulus-oocyte complex (COC), although its physiological significance is not well understood.
Sameera PREMARATNE, Mahiro TAMURA, Omowumi ADEMOLA, Yuki MURANISHI, Masafumi TETSUKA   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source