Results 51 to 60 of about 114,426,039 (308)

Studies on erythropoiesis II. In vitro studies on red cell proliferation under varied oxygen tension [PDF]

, 1964
For the purpose to reveal the mechanism of the stimulated erythropoiesis in anemic condition, the author observed the numerical changes of the erythroblasts from normal rabbit bone marrow cultured under the environment of varied oxygen tensions, and ...
Shibata, Takashi
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446), Seungmin Lee (68256), Qin, Di, Christian Kupatt (402864), Rabea Hinkel, Trenkwalder, Teresa, Rabea Hinkel (402865), Deindl, Elisabeth, Chillo, Omary, Teresa Trenkwalder (402861), Seungmin Lee, Christian Kupatt, Omary Chillo, Lee, Seungmin, Omary Chillo (402862), Kupatt, Christian, Elisabeth Deindl (402863), Di Qin, Hinkel, Rabea, Teresa Trenkwalder, Elisabeth Deindl   +20 more
core   +2 more sources

cAMP Modulators before In Vitro Maturation Decrease DNA Damage and Boost Developmental Potential of Sheep Oocytes

, 2021
To date, the underlying mechanisms by which cAMP modulators act during in vitro maturation to improve oocyte developmental competence are poorly understood. Here, we sought to fill this knowledge gap by evaluating the use of phosphodiesterase inhibitor 3-
Garde, José Julián, Daniela-Alejandra Medina-Chávez, Carolina Maside, José Julián Garde, Ana Josefa Soler, Rocío Fernández-Santos, Medina-Chávez, Daniela-Alejandra, Montoro, Vidal, Peris-Frau, Patricia, Soler, Ana J., Irene Sánchez-Ajofrín, Fernández-Santos, M. Rocío, Sánchez-Ajofrín, Irene, Maside, Carolina, Vidal Montoro, Patricia Peris-Frau   +15 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Human oocyte capacitation culture: Essential step toward hormone‐free assisted reproductive technology

Reproductive Medicine and Biology
Background In vitro oocyte maturation (IVM) is not a novel concept; however, its wide‐scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Johan Smitz, Flor Sánchez, Sergio Romero, Heidi Van Ranst, Ellen Anckaert, Robert B. Gilchrist, Tuong M. Ho, Lan N. Vuong, Yoshiharu Morimoto   +8 more
doaj   +1 more source

Effects of collagen gel configuration on behaviour of vascular smooth muscle cells in vitro: association with vascular morphogenesis.

, 2000
The growth, behavior, and contractile protein expression of rabbit aortic smooth muscle cells (SMC) grown on, between layers, or within a collagen gel was investigated by confocal laser scanning fluorescence microscopy and Western analysis.
Campbell, JH, Hayward, IP, Rolfe, BE, Campbell, Gordon R., Campbell, GR, Campbell, Julie H., Hayward, Ian Philip, Rolfe, Barbara E., Song, J, Song, Jian   +9 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Maturation, reproduction, and broodstock technology [PDF]

, 1988
To download the whole book, click here.Following a review of first maturation in Penaeus monodon , details are given of endocrine, nutritional and environmental methods of induced maturation used in aquaculture.
Primavera, Jurgenne
core   +1 more source

Efecto de gonadotropinas sobre la maduración y desarrollo embrionario de oocitos bovinos cultivados in vitro

Revista Mvz Cordoba, 2010
Objetivo. Evaluar el efecto de las hormonas FSH y LH sobre las tasas de maduración, fertilización y desarrollo embrionario in vitro. Materiales y métodos.
Roger Salgado O, Oscar Vergara G, Leonardo Ramirez P   +2 more
doaj   +1 more source