Results 11 to 20 of about 1,720,158 (168)
Progress in melanoma modelling in vitro [PDF]
Experimental Dermatology, 2018 AbstractMelanoma is one of the most studied neoplasia, although laboratory techniques used for investigating this tumor are not fully reliable. Animal models may not predict the human response due to differences in skin physiology and immunity. In addition, international guidelines recommend to develop processes that contribute to the reduction ...
Marconi, Alessandra +3 more
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Modeling Tumor Microenvironments In Vitro [PDF]
Journal of Biomechanical Engineering, 2014 Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels.
Mingming Wu, Melody A. Swartz
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Models of in vitro spermatogenesis [PDF]
Spermatogenesis, 2012 Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation process is more or less completely dependent upon the cells being located within the ...
Hunter, D. +3 more
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In Vitro Models for Neurogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The process of generating new neurons of different phenotype and function from undifferentiated stem and progenitor cells starts at very early stages of development and continues in discrete regions of the mammalian nervous system throughout life. Understanding mechanisms underlying neuronal cell development, biology, function, and interaction with ...
Hassan, Azari, Brent A, Reynolds
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In vitro Modeling of Embryonal Tumors [PDF]
Frontiers in Cell and Developmental Biology, 2021 A subset of pediatric tumors affects very young children and are thought to arise during fetal life. A common theme is that these embryonal tumors hijack developmental programs, causing a block in differentiation and, as a consequence, unrestricted proliferation.
Lars Custers +5 more
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Stem Cells, 2012 Abstract The current resurgence of interest in the cancer stem cell (CSC) hypothesis as possibly providing a unifying theory of cancer biology is fueled by the growing body of work on normal adult tissue stem cells and the promise that CSC may hold the key to one of the central problems of clinical oncology: tumor recurrence.
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Journal of Investigative Dermatology, 1996 To help elucidate the factors responsible for the infundibular changes seen in acne, the human sebaceous pilosebaceous infundibulum was isolated by microdissection and maintained for 7 d in keratinocyte serum-free medium supplemented with 50 micrograms/ml bovine pituitary extract, 100 units/ml penicillin and streptomycin, 2.5 micrograms/ml amphotericin
Guy, Robert +2 more
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In Vitro Models, In Vivo Models, and Pharmacokinetics: What Can We Learn from In Vitro Models? [PDF]
Clinical Infectious Diseases, 2001 In vitro pharmacokinetic models of infection can make an important contribution to the study of the pharmacodynamic properties of an antibacterial agent. In conjunction with animal and human pharmacodynamic evaluations, they provide data to allow for the optimization of drug dosing regimens.
A, MacGowan, C, Rogers, K, Bowker
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In vitro Models of Neurodegenerative Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2020 Neurodegenerative diseases are progressive degenerative conditions characterized by the functional deterioration and ultimate loss of neurons. These incurable and debilitating diseases affect millions of people worldwide, and therefore represent a major global health challenge with severe implications for individuals and society.
Anna Slanzi +5 more
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Modeling the Leukemia Microenviroment In Vitro [PDF]
Frontiers in Oncology, 2020 Over the last decade, the active role of the microenvironment in the pathogenesis, development and drug resistance of B cell malignancies has been clearly established. It is known that the tissue microenvironment promotes proliferation and drug resistance of leukemic cells suggesting that successful treatments of B cell malignancies must target the ...
Cristina Scielzo +3 more
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