Results 41 to 50 of about 2,928,750 (309)
Mancozeb impairs the ultrastructure of mouse granulosa cells in a dose-dependent manner [PDF]
, 2018 Mancozeb, an ethylene bis-dithiocarbamate, is widely used as a fungicide and exerts reproductive toxicity in vivo and in vitro in mouse oocytes by altering spindle morphology and impairing the ability to fertilize.
Antonouli, S +9 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman +7 more
wiley +1 more source
Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines
Advanced Biomedical Research, 2016 Background: Cell culture techniques have many advantages for investigation of drug transport to target organ like liver. HepG2 and Huh-7 are two cell lines available from hepatoma that can be used as a model for hepatic drug transport.
Melva Louisa +4 more
doaj +1 more source
Pharmaceutics, 2022 (1) Background: Sutures with triclosan (TS) are used to reduce the risk of surgical site infections (SSI), but most clinical trials are inconclusive. The traceability of SSI risk to antimicrobial activity in operated tissues is needed.
Frederic Christopher Daoud +2 more
doaj +1 more source
Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease [PDF]
, 2019 The in vitro study of the pathogenesis of inflammatory bowel disease (IBD) requires a cell model which closely reflects the characteristics of the in vivo intestinal epithelium.
Dosh, Rasha H +3 more
core +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
In Vitro Human Liver Model for Toxicity Assessment with Clinical and Preclinical Instrumentation
PharmaceuticsThe existing in vitro toxicological models lack translational potential, which makes difficult the application of gathered information to clinical usage.
Eneko Madorran +3 more
doaj +1 more source
Bioengineering, 2021 Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly worldwide. So far, the etiology and the progression of AMD are not well known.
Beatrice Belgio +2 more
doaj +1 more source
Songbird organotypic culture as an in vitro model for interrogating sparse sequencing networks [PDF]
, 2017 Sparse sequences of neuronal activity are fundamental features of neural circuit computation; however, the underlying homeostatic mechanisms remain poorly understood. To approach these questions, we have developed a method for cellular-resolution imaging
Blute, Todd +7 more
core +1 more source
Modelling germ cell development in vitro [PDF]
Molecular Human Reproduction, 2008 Germ cells have a critical role in mediating the generation of genetic diversity and transmitting this information across generations. Furthermore, gametogenesis is unique as a developmental process in that it generates highly-specialized haploid gametes from diploid precursor stem cells through meiosis. Despite the importance of this process, progress
Childs, Andrew J +2 more
openaire +3 more sources