Results 51 to 60 of about 2,928,750 (309)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Myocardial Tissue Engineering: In Vitro Models [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Modeling integrated human physiology in vitro is a formidable task not yet achieved with any of the existing cell/tissue systems. However, tissue engineering is becoming increasingly successful at authentic representation of the actual environmental milieu of tissue development, regeneration and disease progression, and in providing real-time insights ...
G. Vunjak Novakovic, T. Eschenhagen, C. Mummery   +2 more
openaire   +3 more sources

In vitro models of intracerebral hemorrhage

Brain Hemorrhages, 2022
Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research.
Bilal Syed, Abhijit Nirwane, Yao Yao
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Development of idealized human aortic models for in vitro and in silico hemodynamic studies

Frontiers in Cardiovascular Medicine
BackgroundThe aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation. Despite its importance, there is a notable lack of idealized models for experimental and computational studies.ObjectiveThis study ...
Hamid Mansouri, Muaz Kemerli, Muaz Kemerli, Robroy MacIver, Omid Amili   +4 more
doaj   +1 more source

Effect of Scrapie Prion Infection in Ovine Bone Marrow-Derived Mesenchymal Stem Cells and Ovine Mesenchymal Stem Cell-Derived Neurons

Animals, 2021
Scrapie is a prion disease affecting sheep and goats and it is considered a prototype of transmissible spongiform encephalopathies (TSEs). Mesenchymal stem cells (MSCs) have been proposed as candidates for developing in vitro models of prion diseases ...
Laura García-Mendívil, Diego R. Mediano, Adelaida Hernaiz, David Sanz-Rubio, Francisco J. Vázquez, Belén Marín, Óscar López-Pérez, Alicia Otero, Juan J. Badiola, Pilar Zaragoza, Laura Ordovás, Rosa Bolea, Inmaculada Martín-Burriel   +12 more
doaj   +1 more source

In vitro models for investigating itch

Frontiers in Molecular Neuroscience, 2022
Itch (pruritus) is a sensation that drives a desire to scratch, a behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch is a hallmark symptom and in which prolonged scratching can induce damage.
Hendrik Mießner, Hendrik Mießner, Judith Seidel, Ewan St. John Smith   +3 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Preparation of chitosan‐embedded recombinant human epidermal growth factor nanoparticles as accelerating compounds for skin remodelling in chronic lesions

Micro & Nano Letters, 2023
The chronic lesion has become a major biological difficulty. Using nanoparticles as drug delivery systems is remarkable nowadays. The unique properties of chitosan in combination with epidermal growth factor (EGF) can accelerate the wound‐healing process.
Saadeh Hashemi, Elnaz Mihandoost, Sepideh Khaleghi   +2 more
doaj   +1 more source

Mechanical Intermittent Compression Affects the Progression Rate of Malignant Melanoma Cells in a Cycle Period-Dependent Manner

Diagnostics, 2021
Static mechanical compression is a biomechanical factor that affects the progression of melanoma cells. However, little is known about how dynamic mechanical compression affects the progression of melanoma cells.
Takashi Morikura, Shogo Miyata
doaj   +1 more source