The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]
, 2019 Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Dag, Ramazan +4 more
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Raziskovalni modeli raka sečnega mehurja za izboljšanje diagnostike in zdravljenja
Zdravniški Vestnik, 2020 Rak sečnega mehurja je ena najpogostejših rakavih bolezni pri moških in ima visoko stopnjo ponovljivosti, zaradi česar predstavlja velik ekonomski in socialni problem.
Daša Zupančič, Samo Hudoklin
doaj +1 more source
Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]
, 1981 The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
A.F.G. Stevenson +44 more
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Informing Selection of Nanomaterial Concentrations for ToxCast In Vitro Testing based on Occupational Exposure Potential [PDF]
, 2011 Background: Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable.
Gangwal, Sumit +6 more
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Single dose pharmacodynamics of amphotericin B against Aspergillus species in an in vitro pharmacokinetic/pharmacodynamic model [PDF]
, 2013 Conventional MIC testing of amphotericin B results in narrow MIC ranges challenging the detection of resistant strains. In order to discern amphotericin B pharmacodynamics, the in vitro activity of amphotericin B was studied against Aspergillus isolates ...
Al-Saigh, Rafal +5 more
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Modeling the Leukemia Microenviroment In Vitro [PDF]
Frontiers in Oncology, 2020 Over the last decade, the active role of the microenvironment in the pathogenesis, development and drug resistance of B cell malignancies has been clearly established. It is known that the tissue microenvironment promotes proliferation and drug resistance of leukemic cells suggesting that successful treatments of B cell malignancies must target the ...
Cristina Scielzo +3 more
openaire +3 more sources
Animals, 2022 Bladder cancer (BC) constitutes approximately 2% of all spontaneously occurring cancers in dogs. It is characterized by a devastating clinical course in most cases, which emphasizes a constant need for the development of novel methods of disease ...
Łukasz Nowak +4 more
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Developing preclinical models of neuroblastoma: driving therapeutic testing
BMC Biomedical Engineering, 2019 Despite advances in cancer therapeutics, particularly in the area of immuno-oncology, successful treatment of neuroblastoma (NB) remains a challenge. NB is the most common cancer in infants under 1 year of age, and accounts for approximately 10% of all ...
Kimberly J. Ornell, Jeannine M. Coburn
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A modular in vitro flow model to analyse blood-surface interactions under physiological conditions
Current Directions in Biomedical Engineering, 2021 Newly developed materials for blood-contacting devices need to undergo hemocompatibility testing to prove compliance with clinical requirements. However, many current in vitro models disregard the influence of flow conditions and blood exchange as it ...
Valtin Juliane +5 more
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Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2
Cells, 2021 The cellular immune response plays an important role in COVID-19, caused by SARS-CoV-2. This feature makes use of in vitro models’ useful tools to evaluate vaccines and biopharmaceutical effects.
Juliana G. Melgaço +25 more
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