Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks
Drug Design, Development and Therapy, 2013 Aleksander Mendyk,1 Pawel Tuszynski,1 Sebastian Polak,2 Renata Jachowicz1 1Department of Pharmaceutical Technology and Biopharmaceutics, 2Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland ...
Mendyk A +3 more
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In vitro placental model optimization for nanoparticle transport studies
International Journal of Nanomedicine, 2012 Laura Cartwright1, Marie Sønnegaard Poulsen2, Hanne Mørck Nielsen3, Giulio Pojana4, Lisbeth E Knudsen2, Margaret Saunders1, Erik Rytting2,51Bristol Initiative for Research of Child Health (BIRCH), Biophysics Research Unit, St ...
Cartwright L +6 more
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Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. [PDF]
, 2022 PURPOSE: In vivo, the circadian clock drives 24-h rhythms in human physiology. Isolated cells in vitro retain a functional clockwork but lack necessary timing cues resulting in the rapid loss of tissue-level circadian rhythms.
Lee, David A +10 more
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In vitro cancer models as an approach to identify targetable developmental phenotypes in cancer stem cells [PDF]
, 2023 Cancer therapeutics are often highly toxic to the patient, and they often elicit rapid resistance in the tumour. Recent advances have suggested a potential new way in which we may improve on this, through two important concepts: (1) that multitudinous ...
Adrian Biddle, Biddle, A
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Reconstruction of destruction – in vitro reconstitution methods in autophagy research [PDF]
, 2018 International audienceAutophagy is one of the most elaborative membrane remodeling systems in eukaryotic cells. Its major function is to recycle cytoplasmic material by delivering it to lysosomes for degradation.
Wollert, Thomas, Moparthi, Satish Babu
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, 2023 A better understanding of the mechanisms behind adverse health effects caused by airborne fine particles and nanoparticles (NP) is essential to improve risk assessment and identification the most critical particle exposures.
Ulrika Johansson +17 more
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In Vitro Pharmacokinetic/Pharmacodynamic Modeling of Voriconazole Activity against Aspergillus Species in a New In Vitro Dynamic Model [PDF]
, 2012 The pharmacodynamics (PD) of voriconazole activity against Aspergillus spp. were studied using a new in vitro dynamic model simulating voriconazole human pharmacokinetics (PK), and the PK-PD data were bridged with human drug exposure to assess the ...
Zerva, Loukia +4 more
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Human ubiquitin-like proteins as central coordinators in autophagy [PDF]
, 2018 International audienceAutophagy is one of the most versatile recycling systems of eukaryotic cells. It degrades diverse cytoplasmic components such as organelles, protein aggregates, ribosomesand multi-enzyme complexes.
Wollert, Thomas, Mohan, Jagan
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A modular in vitro flow model to analyse blood-surface interactions under physiological conditions
Current Directions in Biomedical Engineering, 2021 Newly developed materials for blood-contacting devices need to undergo hemocompatibility testing to prove compliance with clinical requirements. However, many current in vitro models disregard the influence of flow conditions and blood exchange as it ...
Valtin Juliane +5 more
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Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2
Cells, 2021 The cellular immune response plays an important role in COVID-19, caused by SARS-CoV-2. This feature makes use of in vitro models’ useful tools to evaluate vaccines and biopharmaceutical effects.
Juliana G. Melgaço +25 more
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