Results 51 to 60 of about 1,720,158 (168)

In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy

Pharmaceutics, 2020
Periodontal therapy using antimicrobials that are topically applied requires slow or controlled release devices. The in vitro antimicrobial activity of biodegradable polymer formulations that contain a new minocycline lipid complex (P-MLC) was evaluated.
Jan-Luca Schmid, Martin Kirchberg, Sandra Sarembe, Andreas Kiesow, Anton Sculean, Karsten Mäder, Mirko Buchholz, Sigrun Eick   +7 more
doaj   +1 more source

Mechanistic in vitro–in vivo extrapolation (IVIVE) approach using a biomimetic in vitro system for the prediction of hepatic clearance

Computational and Structural Biotechnology Journal
This study proposes a novel in vitro–in vivo extrapolation (IVIVE) strategy that integrates a patented biomimetic in vitro system with pharmacokinetic modeling to improve the prediction of in vivo drug kinetics.
Seongwon Park, Sun-Sook Song, Woojin Jung, Hwi-yeol Yun, Soyoung Lee, Sun-Woong Kang, Jung-Woo Chae   +6 more
doaj   +1 more source

Profiling the Course of Resolving vs. Persistent Inflammation in Human Monocytes: The Role of IL-1 Family Molecules

Frontiers in Immunology, 2020
Monocytes and macrophages have a central role in all phases of an inflammatory reaction. To understanding the regulation of monocyte activation during a physiological or pathological inflammation, we propose two in vitro models that recapitulate the ...
Paola Italiani, Ettore Mosca, Giacomo Della Camera, Daniela Melillo, Paola Migliorini, Luciano Milanesi, Diana Boraschi   +6 more
doaj   +1 more source

The preparation of rat cerebellar synaptosome and its applications in studying presynaptic membrane proteins

مجله دانشگاه علوم پزشکی گرگان, 2007
Background&Objective: Synaptosomes as an In Vitro model have unique properties. So, general method of preparation and their applications in studying presynaptic mebrane proteins are introduced.
Hosseini SM, Asgari AR, Mehrani HA, Khoshbaten A   +3 more
doaj  

Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity

Biomedicines
Background/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Courtney Sakolish, Han-Hsuan D. Tsai, Hsing-Chieh Lin, Piyush Bajaj, Remi Villenave, Stephen S. Ferguson, Jason P. Stanko, Richard A. Becker, Philip Hewitt, Weihsueh A. Chiu, Ivan Rusyn   +10 more
doaj   +1 more source

Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer

Frontiers in Oncology, 2020
Colorectal cancer is the second most common cancer diagnosed in men and the third most commonly occurring in women worldwide. Interactions between cells and the surrounding extracellular matrix (ECM) are involved in tumor development and progression of ...
Cuong Cao Le, Cuong Cao Le, Cuong Cao Le, Amar Bennasroune, Amar Bennasroune, Benoit Langlois, Benoit Langlois, Stéphanie Salesse, Stéphanie Salesse, Camille Boulagnon-Rombi, Camille Boulagnon-Rombi, Camille Boulagnon-Rombi, Hamid Morjani, Hamid Morjani, Stéphane Dedieu, Stéphane Dedieu, Aline Appert-Collin, Aline Appert-Collin   +17 more
doaj   +1 more source

Organoids: a better in vitro model [PDF]

Nature Methods, 2017
3D human cell cultures are changing the way scientists model organ development and function—but they have their own set of complications.
openaire   +2 more sources

Concentration-Dependent Enrichment of Linezolid-Resistant Staphylococcus aureus in an in vitro Dynamic Model

Антибиотики и Химиотерапия, 2020
To establish the relationships between the enrichment of resistant Staphylococcus aureus mutants and the ratio of daily area under the concentration - time curve (AUC24) to the MIC of linezolid, a mixed inoculum of linezolid-susceptible and -resistant ...
K. N. Alieva, E. N. Strukova, M. V. Golikova, Yu. A. Portnoy, A. A. Firsov   +4 more
doaj  

A human relevant in vitro alveolar epithelial barrier model to assess inhaled pollutant hazard

Scientific Reports
Relevant in vitro models could reduce the requirement for in vivo testing and allow higher throughput for imperative toxicological or pharmaceutical hazard testing.
Joshua W. P. Bateman, Kirsty Meldrum, Sarah M. Mitchell, Ulla Vogel, Martin J. D. Clift   +4 more
doaj   +1 more source

In-vitro models of human endometriosis.

Experimental and therapeutic medicine, 2020
Endometriosis is one of the most common benign gynecological diseases in women of reproductive age worldwide. In past decades, a number of in-vitro models have been used to investigate the pathology and therapeutic methods for the treatment of endometriosis.
openaire   +2 more sources