Results 101 to 110 of about 1,346,069 (268)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Bridging the gap: From petri dish to patient - Advancements in translational drug discovery
HeliyonTranslational research serves as the bridge between basic research and practical applications in clinical settings. The journey from ''bench to bedside'' is fraught with challenges and complexities such as the often-observed disparity between how ...
Mohamed El-Tanani +4 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
In Vitro models of epidermal differentiation.
Folia medica, 1998 The differentiation program followed by the epidermal keratinocyte in skin is intended to continuously produce and maintain a cornified layer made of fully keratinized cells. This outer layer of the body provides a certain protection against external pathogens and chemical or physical agents, together with a barrier that prevents loss of body fluids ...
Poumay, Yves, Smekens, Michèle
openaire +2 more sources
Twenty years of in vitro nanotoxicology: how AI could make the difference
Frontiers in ToxicologyMore than two decades ago, the advent of Nanotechnology has marked the onset of a new and critical field in science and technology, highlighting the importance of multidisciplinary approaches to assess and model the potential human hazard of newly ...
Luisa Campagnolo +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Impact of oxygen–ozone mixture on cellular functions: a biochemical perspective across cell types
Molecular MedicineAdaptive responses induced by low-dose stressors can enhance cellular resilience and system functionality. In this context, ozone, a potent oxidant known for its UV-shielding and antimicrobial properties, has attracted interest over the past decades for ...
Ayesha Khalid +3 more
doaj +1 more source
Frontiers in Bioengineering and BiotechnologyThe clinical translation of endovascular implants and new therapeutics for aortic aneurysms depend broadly on the reliability of the experimental testing models utilized. In vivo models present serious ethical and logistical limitations.
Saurav Ranjan Mohapatra +5 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source