Results 131 to 140 of about 2,565,113 (352)

Detection of intermediates and kinetic control during assembly of bacteriophage P22 procapsid [PDF]

, 2008
Bacteriophage P22 serves as a model for the assembly and maturation of other icosahedral double-stranded DNA viruses. P22 coat and scaffolding proteins assemble in vitro into an icosahedral procapsid, which then expands during DNA packaging (maturation).
Abendon, Canady, Casjens, Ceres, Earnshaw, Endres, Falkner, Feigin, Fowler, Galisteo, Golub, Guinier, Hendrix, Hiro Tsuruta, Jiang, Kang, Kenneth H. French, Kihara, King, Lanman, Paatero, Paatero, Parent, Parent, Parent, Parker, Parker, Parker, Parker, Parker, Peter E. Prevelige, Prasad, Prevelige, Prevelige, Prevelige, Quinn, Reddy, Roman Tuma, Sakalian, Stockley, Stray, Sun, Svergun, Thuman-Commike, Thuman-Commike, Thuman-Commike, Tuma, Wang, Wang, Wyckoff, Zhang, Zlotnick, Zlotnick, Zlotnick   +53 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EFFECT OF POLYETHYLENE GLYCOL ON IN VITRO GAS PRODUCTION AND DIGESTIBILITY OF TANNIN CONTAINING FEEDSTUFFS FROM NORTH AFRICAN ARID ZONE

Tropical and Subtropical Agroecosystems, 2009
The influence of tannins present in arid zone forages from North Africa: Aristida plumosa, Danthonia forskahlii, Astragalus gombiformis, Genista saharae, two date palm fractions (leaves and racemes), and vetch-oat hay taken as control on in vitro gas ...
Arhab Rabah, Macheboeuf Didier, Aggoun Moufida, Bousseboua Hacène, Viala Didier Viala1, Besle JeanMichel   +5 more
doaj  

The Usefulness of Retinoic Acid Supplementation during In Vitro Oocyte Maturation for the In Vitro Embryo Production of Livestock: A Review

Animals, 2019
Retinoic acid (RA) is an indigenous metabolite and descriptive physiologically functioning constituent of vitamin A. Retinoids were documented as vital regulators for cell development and distinction, embryonic growth, and reproductive function in both ...
Sameh A. Abdelnour, Mohamed E. Abd El-Hack, Ayman Abdel-Aziz Swelum, Islam M. Saadeldin, Ahmed E. Noreldin, Asmaa F. Khafaga, Mohsen G. Al-Mutary, Muhammad Arif, El-Sayed O. S. Hussein   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The effect of silkworms (Bombyx mori) chitosan on rumen fermentation, methanogenesis, and microbial population in vitro [PDF]

Veterinary World
Background and Aim: Ruminant enteric methane (CH4) is one of the largest sources of greenhouse gases that contribute to global warming. To minimize environmental harm caused by ruminants’ CH4 production, natural substances can be used to suppress it ...
Yemima Gresia Sagala, Lincah Andadari, Tri Hadi Handayani, Mohammad Miftakhus Sholikin, Ainissya Fitri, Rusli Fidriyanto, Rohmatussolihat Rohmatussolihat, Roni Ridwan, Wulansih Dwi Astuti, Yantyati Widyastuti, Dilla Mareistia Fassah, Indah Wijayanti, Ki Ageng Sarwono   +12 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Immunological and Physiological Differences Between Layer- and Broiler Chickens after Concurrent Intratracheal Administration of Lipopolysaccharide and Human Serum Albumin [PDF]

, 2010
Layers and broilers were concurrently intratracheally challenged with 0.5 mg Lipopolysaccharide (LPS) and 0.1 mg Human Serum Albumin (HuSA) at 3 weeks of age.
Freke, P., Koopmanschap, R.E., Lammers, A., Parmentier, H.K., Vries Reilingh, G., de   +4 more
core   +1 more source