Results 141 to 150 of about 2,565,113 (352)
, 2019 Cellulose over-producing wrinkly spreader mutants of Pseudomonas fluorescens SBW25 have been the focus of much investigation, but conditions promoting the production of cellulose in ancestral SBW25, its effects and consequences have escaped in-depth ...
Ardré, M., Dufour, D., Rainey, P.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
AnimalsThe kodkod (Leopardus guigna) is a vulnerable wild felid native to South America whose population is steadily declining. ARTs offer valuable tools for the preservation of its genetic diversity. Our study provides the first evaluation of the morphological
Deyna Toledo-Saldivia +8 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. [PDF]
, 2002 We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFkappaB activation and collagenase-1 (CL-1)/matrix ...
Werb, Zena, Werner, Erica
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Meta-analysis of the effects of bovine in vitro embryo production on gene expression
AnimalBovine embryo production, with both in vivo and in vitro production methods being employed, has acquired worldwide importance. In vitro culture systems, however, often fail to fully replicate the in vivo environment, potentially leading to altered gene ...
G. Neufeld +3 more
doaj +1 more source
In vitro production of naked mole-rats' blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection. [PDF]
Sci Rep, 2023 Simone R +6 more
europepmc +1 more source
How to read a book both ways: Detecting and understanding the mantled phenotype in oil palm [PDF]
, 2010 The mantled epigenetic somaclonal variation of oil palm has generated a vast array of research endeavours, both within and outside of our lab. Because of its unpredictable, detrimental effect on palm oil production, we need to discriminate the variant ...
Adler, Sophie +6 more
core