Results 101 to 110 of about 25,424 (210)

Proteome of the testicular cell-conditioned medium supports germ cell differentiation in vitro

Journal of Advanced Veterinary and Animal Research
Objective: This study aimed to evaluate the effect of testicular cell conditioned medium (TCCM) on in vitro male germ cell differentiation and provide a proteomic profile of TCCM. Materials and Methods: TCCM was collected from 5-day-old mouse testicular
Wahono Esthi Prasetyaningtyas, Ni Wayan Kurniani Karja, Srihadi Agungpriyono, I Ketut Mudite Adnyane, Kusdiantoro Mohamad, Mokhamad Fahrudin   +5 more
doaj   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

Impact of Chemotherapy on Sperm Functional Characteristics in Patients With Testicular Germ Cell Tumours

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec, Ondrej Simonik, Zuzana Kratka, Lukas Ded, Jana Vondrakova, Maryam Qasemi, Barbora Bryndova, Michala Krejci, Daniela Spevakova, Vishma Pratap Sur, Radomir Kren, Tomas Hradec, Pavel Skrobanek, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Pavla Postlerova, Katerina Komrskova   +18 more
wiley   +1 more source

Induction of spermatogenesis under 3-dimentional tissue culture conditions by in vitro transplantation of spermatogonial stem cells isolated from human frozen-thawed testis tissue [PDF]

, 2019
Mahdi Mohaqiq, Mansoureh Movahedin, Zohreh Mazaheri, Naser Amirjannati   +3 more
openalex   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

BOLL‐Containing Aggregates Mediate the Translational Regulation During Human Oogenesis

Cell Proliferation, EarlyView.
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Ying Li, Lingya Mao, Boyuan Liang, Longxin Xie, Wenpei Xiang, Kehkooi Kee   +5 more
wiley   +1 more source

The dynamic expression of YAP is essential for the development of male germ cells derived from human embryonic stem cells

Scientific Reports
YAP plays a vital role in controlling growth and differentiation in various cell lineages. Although the expression of YAP in mice testicular and spermatogenic cells suggests its role in mammalian spermatogenesis, the role of YAP in the development of ...
Sujittra Khampang, Chanchao Lorthongpanich, Chuti Laowtammathron, Phatchanat Klaihmon, Sukanya Meesa, Wichuda Suksomboon, Nittaya Jiamvoraphong, Pakpoom Kheolamai, Sudjit Luanpitpong, Charles A. Easley, Eisa Mahyari, Surapol Issaragrisil   +11 more
doaj   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, Volume 101, Issue 2, Page 580-601, April 2026.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source