Results 31 to 40 of about 25,424 (210)

Models of in vitro spermatogenesis [PDF]

Spermatogenesis, 2012
Understanding the mechanisms that lead to the differentiation of male germ cells from their spermatogonial stem cells through meiosis to give rise to mature haploid spermatozoa has been a major quest for many decades. Unlike most other cell types this differentiation process is more or less completely dependent upon the cells being located within the ...
Hunter, D., Anand Ivell, R., Danner, S., Ivell, R.   +3 more
openaire   +4 more sources

In vitro spermatogenesis [PDF]

Spermatogenesis, 2012
The generation of functional sperm in vitro has been a goal for almost a century. Until recently, researchers have only succeeded in reproducing the early steps of spermatogenesis. This is not surprising given that spermatogenesis is a complicated process that requires the coordinated efforts of germ cells and several somatic cells within the tubular ...
Song, Hye-Won, Wilkinson, Miles F.
openaire   +2 more sources

Potential clinical value of in vitro spermatogenesis

Biology of Reproduction, 2022
AbstractInfertility has become the third most common disease threatening human health, immediately after tumors and cardiovascular diseases. Male infertility is primarily caused by spermatogenesis disorders that may be classified as either genetic or non-genetic.
Laihua, Li, Yan, Yuan, Jiahao, Sha
openaire   +2 more sources

Transplantation of mouse iPSCs into testis of azoospermic mouse model: in vivo and in vitro study

Artificial Cells, Nanomedicine, and Biotechnology, 2019
This study aimed to induce spermatogenesis in azoospermic testis through induced pluripotent stem cells (iPSCs) derived spermatogonial stem cell-like cells (SSCLCs) after iPSCs in vivo and in vitro transplantation and three-dimensional organ culture. DiI-
Forouzan Rahmani, Mansoureh Movahedin, Zohreh Mazaheri, Masoud Soleimani   +3 more
doaj   +1 more source

Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice

eLife, 2023
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa for assisted reproductive technology.
Laura Moutard, Caroline Goudin, Catherine Jaeger, Céline Duparc, Estelle Louiset, Tony Pereira, François Fraissinet, Marion Delessard, Justine Saulnier, Aurélie Rives-Feraille, Christelle Delalande, Hervé Lefebvre, Nathalie Rives, Ludovic Dumont, Christine Rondanino   +14 more
doaj   +1 more source

Spermatogonial stem cells: Progress and prospects

Asian Journal of Andrology, 2015
Twenty years ago, the transplantation of spermatogonial stem cells (SSCs) from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs.
Mitsuru Komeya, Takehiko Ogawa
doaj   +1 more source

LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions

Biology Direct, 2023
Background Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to explore the role of lncRNA5251 in
Cong Zhang, Dongxin Lu, Tong Niu, Zhongyi Sun, Yandi Wang, Xiao Han, Bohui Xiong, Wei Shen, Qingyuan Sun, Yong Zhao, Weidong Zhang, Yanni Feng   +11 more
doaj   +1 more source

Throughout in vitro first spermatogenic wave: Next-generation sequencing gene expression patterns of fresh and cryopreserved prepubertal mice testicular tissue explants

Frontiers in Endocrinology, 2023
IntroductionSuitable cryopreservation procedures of pre-pubertal testicular tissue associated with efficient culture conditions are crucial in the fields of fertility preservation and restoration.
Ludovic Dumont, Ludovic Dumont, Hélène Lopez Maestre, Hélène Lopez Maestre, Frédéric Chalmel, Louise Huber, Louise Huber, Aurélie Rives-Feraille, Aurélie Rives-Feraille, Laura Moutard, Laura Moutard, Frédérique Bateux, Frédérique Bateux, Christine Rondanino, Christine Rondanino, Nathalie Rives, Nathalie Rives, Nathalie Rives   +17 more
doaj   +1 more source

Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

Middle East Fertility Society Journal, 2020
Background Male infertility is usually caused via the inability to produce adequate quantities of healthy and active sperms. Nicotine (NIC) is an alkaloid organic compound, predominantly found in the leaves of the tobacco plant.
Mohammad Rahimi-Madiseh, Mohsen Mohammadi, Amin Hassanvand, Reza Ahmadi, Maasume Shahmohammadi, Ayoob Rostamzadeh   +5 more
doaj   +1 more source

Advanced bioengineering of male germ stem cells to preserve fertility

Journal of Tissue Engineering, 2021
In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide.
Hossein Eyni, Sadegh Ghorbani, Hojjatollah Nazari, Marziyeh Hajialyani, Sajad Razavi Bazaz, Mahdi Mohaqiq, Majid Ebrahimi Warkiani, Duncan S Sutherland   +7 more
doaj   +1 more source