Results 21 to 30 of about 25,802 (201)

Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration

Frontiers in Endocrinology, 2022
Spermatogonial stem cells (SSCs) are a group of adult stem cells in the testis that serve as the foundation of continuous spermatogenesis and male fertility.
Lei Diao, Paul J. Turek, Constance M. John, Fang Fang, Renee A. Reijo Pera, Renee A. Reijo Pera   +5 more
doaj   +1 more source

Progress and future prospect of in vitro spermatogenesis. [PDF]

Oncotarget, 2017
Infertility has become a major health issue in the world. It affects the social life of couples and of all infertility cases; approximately 40-50% is due to "male factor" infertility. Male infertility could be due to genetic factors, environment or due to gonadotoxic treatment.
Ibtisham F, Wu J, Xiao M, An L, Banker Z, Nawab A, Zhao Y, Li G.   +7 more
europepmc   +4 more sources

Fact or fiction: In vitro spermatogenesis. [PDF]

Spermatogenesis, 2012
Many previous studies have aimed at spermatogenesis of male murine germ cells in vitro, but no efficient system has been established yet that covers the entire process of mammalian spermatogenesis in a culture dish permanently. In this review, we report on the requirements of spermatogenesis and the current state of different culture methods using ...
Reuter K, Schlatt S, Ehmcke J, Wistuba J.   +3 more
europepmc   +4 more sources

Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice

eLife, 2023
Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa for assisted reproductive technology.
Laura Moutard, Caroline Goudin, Catherine Jaeger, Céline Duparc, Estelle Louiset, Tony Pereira, François Fraissinet, Marion Delessard, Justine Saulnier, Aurélie Rives-Feraille, Christelle Delalande, Hervé Lefebvre, Nathalie Rives, Ludovic Dumont, Christine Rondanino   +14 more
doaj   +1 more source

Transplantation of mouse iPSCs into testis of azoospermic mouse model: in vivo and in vitro study

Artificial Cells, Nanomedicine, and Biotechnology, 2019
This study aimed to induce spermatogenesis in azoospermic testis through induced pluripotent stem cells (iPSCs) derived spermatogonial stem cell-like cells (SSCLCs) after iPSCs in vivo and in vitro transplantation and three-dimensional organ culture. DiI-
Forouzan Rahmani, Mansoureh Movahedin, Zohreh Mazaheri, Masoud Soleimani   +3 more
doaj   +1 more source

Throughout in vitro first spermatogenic wave: Next-generation sequencing gene expression patterns of fresh and cryopreserved prepubertal mice testicular tissue explants

Frontiers in Endocrinology, 2023
IntroductionSuitable cryopreservation procedures of pre-pubertal testicular tissue associated with efficient culture conditions are crucial in the fields of fertility preservation and restoration.
Ludovic Dumont, Ludovic Dumont, Hélène Lopez Maestre, Hélène Lopez Maestre, Frédéric Chalmel, Louise Huber, Louise Huber, Aurélie Rives-Feraille, Aurélie Rives-Feraille, Laura Moutard, Laura Moutard, Frédérique Bateux, Frédérique Bateux, Christine Rondanino, Christine Rondanino, Nathalie Rives, Nathalie Rives, Nathalie Rives   +17 more
doaj   +1 more source

Spermatogonial stem cells: Progress and prospects

Asian Journal of Andrology, 2015
Twenty years ago, the transplantation of spermatogonial stem cells (SSCs) from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs.
Mitsuru Komeya, Takehiko Ogawa
doaj   +1 more source

Time-course microarray transcriptome data of in vitro cultured testes and age-matched in vivo testes

Data in Brief, 2020
In vitro spermatogenesis, which produces fertile spermatozoa, has been successfully performed using an organ culture method from murine tissue. Here, we provide a dataset of time-course microarray transcriptome data of in vitro cultured neonate murine ...
Takeru Abe, Hajime Nishimura, Takuya Sato, Harukazu Suzuki, Takehiko Ogawa, Takahiro Suzuki   +5 more
doaj   +1 more source

LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions

Biology Direct, 2023
Background Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to explore the role of lncRNA5251 in
Cong Zhang, Dongxin Lu, Tong Niu, Zhongyi Sun, Yandi Wang, Xiao Han, Bohui Xiong, Wei Shen, Qingyuan Sun, Yong Zhao, Weidong Zhang, Yanni Feng   +11 more
doaj   +1 more source

Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

Middle East Fertility Society Journal, 2020
Background Male infertility is usually caused via the inability to produce adequate quantities of healthy and active sperms. Nicotine (NIC) is an alkaloid organic compound, predominantly found in the leaves of the tobacco plant.
Mohammad Rahimi-Madiseh, Mohsen Mohammadi, Amin Hassanvand, Reza Ahmadi, Maasume Shahmohammadi, Ayoob Rostamzadeh   +5 more
doaj   +1 more source