Time-course microarray transcriptome data of in vitro cultured testes and age-matched in vivo testes
Data in Brief, 2020 In vitro spermatogenesis, which produces fertile spermatozoa, has been successfully performed using an organ culture method from murine tissue. Here, we provide a dataset of time-course microarray transcriptome data of in vitro cultured neonate murine ...
Takeru Abe +5 more
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LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions
Biology Direct, 2023 Background Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to explore the role of lncRNA5251 in
Cong Zhang +11 more
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Potential clinical value of in vitro spermatogenesis
Biology of Reproduction, 2022 AbstractInfertility has become the third most common disease threatening human health, immediately after tumors and cardiovascular diseases. Male infertility is primarily caused by spermatogenesis disorders that may be classified as either genetic or non-genetic.
Laihua, Li, Yan, Yuan, Jiahao, Sha
openaire +2 more sources
Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]
, 2018 Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core +1 more source
Middle East Fertility Society Journal, 2020 Background Male infertility is usually caused via the inability to produce adequate quantities of healthy and active sperms. Nicotine (NIC) is an alkaloid organic compound, predominantly found in the leaves of the tobacco plant.
Mohammad Rahimi-Madiseh +5 more
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Advanced bioengineering of male germ stem cells to preserve fertility
Journal of Tissue Engineering, 2021 In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide.
Hossein Eyni +7 more
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Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]
, 2017 A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di +13 more
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Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits [PDF]
, 2002 Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and ...
Berndtson, William E. +2 more
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Meiotic Chromosome Synapsis and XY-Body Formation In Vitro
Frontiers in Endocrinology, 2021 To achieve spermatogenesis in vitro, one of the most challenging processes to mimic is meiosis. Meiotic problems, like incomplete synapsis of the homologous chromosomes, or impaired homologous recombination, can cause failure of crossover formation and ...
Qijing Lei +3 more
doaj +1 more source
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]
, 2009 Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H. +4 more
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