Results 1 to 10 of about 395,818 (261)

Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas [PDF]

Frontiers in Cell and Developmental Biology
Background and ObjectiveUterine leiomyomas may arise from somatic stem or progenitor cells, leading to abnormal activation, proliferation, and clonal expansion.
Paula Vázquez, Paula Vázquez, Ana Salas, Ana Salas, Silvia Beltrán-Flores, Silvia Beltrán-Flores, Francisco Montes de Oca, Araceli Delgado, Araceli Delgado, Araceli Delgado, Teresa A. Almeida, Teresa A. Almeida, Teresa A. Almeida   +12 more
doaj   +2 more sources

Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc [PDF]

JOR Spine, 2022
Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying ...
Shirley N. Tang, Andres F. Bonilla, Nadeen O. Chahine, Aimee C. Colbath, Jeremiah T. Easley, Sibylle Grad, Lisbet Haglund, Christine L. Le Maitre, Victor Leung, Annette M. McCoy, Devina Purmessur, Simon Y. Tang, Stephan Zeiter, Lachlan J. Smith   +13 more
doaj   +2 more sources

Intestine Explants in Organ Culture: A Tool to Broaden the Regenerative Studies in Echinoderms [PDF]

Journal of Marine Science and Engineering, 2022
The cellular events underlying intestine regrowth in the sea cucumber Holothuria glaberrima have been described by our group. Currently, the molecular and signaling mechanisms involved in this process are being explored.
Samir A. Bello, José E. García-Arrarás   +1 more
doaj   +2 more sources

Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc [PDF]

JOR Spine
Background Disc degeneration is associated with repetitive violent injuries. This study aims to explore the impact of repetitive strikes loading on the biology and biomechanics of intervertebral discs (IVDs) using an organ culture model.
Jiaxiang Zhou, Jianmin Wang, Jianfeng Li, Zhengya Zhu, Zhongyuan He, Junhong Li, Tao Tang, Hongkun Chen, Yukun Du, Zhen Li, Manman Gao, Zhiyu Zhou, Yongming Xi   +12 more
doaj   +2 more sources

Regeneration of amputated mice digit tips by including Wnt signaling pathway with CHIR99021 and IWP-2 chemicals in limb organ culture system [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Mammals have limited limb regeneration compared to amphibians. The role of Wnt signaling pathways in limb regeneration has rarely been studied.
Leila Taghiyar, Fatemeh Bijarchian, Mohamadreza Baghban Eslaminejad, Mahshad Doraj   +3 more
doaj   +2 more sources

The influence of intervertebral disc overloading on nociceptor calcium flickering

JOR Spine, 2023
Introduction Mechanical overloading can trigger a degenerative‐like cascade in an organ culture of intervertebral disc (IVD). Whether the overloaded IVD can influence the activation of nociceptors (i.e., the damage sensing neurons) remains unknown.
Jan Gewiess, Janick Eglauf, Astrid Soubrier, Sibylle Grad, Mauro Alini, Marianna Peroglio, Junxuan Ma   +6 more
doaj   +1 more source

Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model

JOR Spine, 2021
Introduction The goal of this study is to characterize transcriptome changes and gene regulation networks in an organ culture system that mimics early post‐traumatic intervertebral disc (IVD) degeneration.
Shangbin Cui, Zhiyu Zhou, Xu Chen, Fuxin Wei, R. Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li   +7 more
doaj   +1 more source

SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues

Viruses, 2022
SARS-CoV-2 Omicron variant has been characterized by decreased clinical severity, raising the question of whether early variant-specific interactions within the mucosal surfaces of the respiratory tract could mediate its attenuated pathogenicity.
Or Alfi, Marah Hamdan, Ori Wald, Arkadi Yakirevitch, Ori Wandel, Esther Oiknine-Djian, Ben Gvili, Hadas Knoller, Noa Rozendorn, Hadar Golan Berman, Sheera Adar, Olesya Vorontsov, Michal Mandelboim, Zichria Zakay-Rones, Menachem Oberbaum, Amos Panet, Dana G. Wolf   +16 more
doaj   +1 more source

In vitro spermatogenesis: In search of fully defined conditions

Frontiers in Cell and Developmental Biology, 2023
A complete reconstruction of spermatogenesis in vitro under fully defined conditions still has not been achieved. However, many techniques have been proposed to get closer to that aim. Here we review the current progress in the field.
A. Yu. Kulibin, E. A. Malolina
doaj   +1 more source

Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube

Frontiers in Immunology, 2018
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva. Asymptomatic or unnoticed infections in the lower reproductive tract of women can lead to
Jonathan D. Lenz, Joseph P. Dillard
doaj   +1 more source