Results 41 to 50 of about 4,938,266 (305)
Frontiers in Bioengineering and Biotechnology, 2020 Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD).
Zhen Li +13 more
doaj +1 more source
Journal of Investigative Surgery, 2022 Aim: This review summarized the recent intervertebral disc degeneration (IDD) models and described their advantages and potential disadvantages, aiming to provide an overview for the current condition of IDD model establishment and new ideas for new ...
Yidian Wang +7 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Organ and tissue donation: Exploring the needs of families
, 2003 Relatives of potential organ donors are the most critical link in maintaining organ availability, as they must express their lack of objection before organ retrieval may take place. The often sudden and unexpected nature of the death of a potential organ
Payne, S. +5 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Офтальмохирургия, 2017 Purpose. To investigate in an experimental and morphological ex vivo research a tissue reaction of human cadaver donor cornea to the implantation of intra-corneal lenses (ICL)Material and methods.
B. E. Malyugin +6 more
doaj
AgricultureEpigeal cotyledons with excised embryonic axes are often used as a model system to study the processes of cell division and expansion. These processes are regulated by diverse phytohormones and signaling molecules.
Asya Petrova +3 more
doaj +1 more source
eLife, 2022 In recent years, live-imaging techniques have been developed for the adult midgut of Drosophila melanogaster that allow temporal characterization of key processes involved in stem cell and tissue homeostasis.
Marco Marchetti +2 more
doaj +1 more source
Supplementary material. Autologous iPSC-derived four-organ-chip
, 2019 Supplementary material. Autologous iPSC-derived four-organ-chipMicrophysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development.
Lin, Grace (7363457) +17 more
core +1 more source