Results 51 to 60 of about 395,818 (261)

Three-dimensional human skin models to understand <i>Staphylococcus aureus </i> skin colonization and infection

Frontiers in Immunology, 2014
Staphylococcus aureus is both a major bacterial pathogen as well as a common member of the human skin microbiota. Due to its widespread prevalence as an asymptomatic skin colonizer and its importance as a source of skin and soft tissue infections, an ...
Lauren ePopov, Joanna eKovalski, Guido eGrandi, Fabio eBagnoli, Manuel R. Amieva, Manuel R. Amieva   +5 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Steroid Production and Follicular Development of Neonatal Mouse Ovary during in vitro Culture [PDF]

International Journal of Fertility and Sterility, 2013
Background: The aim of this study was to investigate follicular growth and steroid production in neonatal mouse ovary during in vitro culture. Materials and Methods: In this experimental study, 7-day-old mouse whole ovaries were cultured in α-MEM ...
Shabnam Abdi, Mojdeh Salehnia, Saman Hosseinkhani   +2 more
doaj  

Observation of Dynamic Cellular Migration of the Medial Edge Epithelium of the Palatal Shelf in vitro

Frontiers in Physiology, 2019
Palatal fusion is a critical step during palatogenesis. In this fusing interface, the epithelial sheets need to be removed in order to achieve mesenchymal continuity.
Gozo Aoyama, Hiroshi Kurosaka, Ayaka Oka, Kohei Nakatsugawa, Sayuri Yamamoto, Safiye Esra Sarper, Safiye Esra Sarper, Yu Usami, Satoru Toyosawa, Toshihiro Inubushi, Yukako Isogai, Takashi Yamashiro   +11 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Papain Injection Creates a Nucleotomy-like Cavity for Testing Gels in Intervertebral Discs

Gels
Biomaterials, such as hydrogels, have an increasingly important role in the development of regenerative approaches for the intervertebral disc. Since animal models usually resist biomaterial injection due to high intradiscal pressure, preclinical testing
Jan Ulrich Jansen, Graciosa Quelhas Teixeira, Andrea Vernengo, Sybille Grad, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Molecular architecture underlying fluid absorption by the developing inner ear

eLife, 2017
Mutations of SLC26A4 are a common cause of hearing loss associated with enlargement of the endolymphatic sac (EES). Slc26a4 expression in the developing mouse endolymphatic sac is required for acquisition of normal inner ear structure and function. Here,
Keiji Honda, Sung Huhn Kim, Michael C Kelly, Joseph C Burns, Laura Constance, Xiangming Li, Fei Zhou, Michael Hoa, Matthew W Kelley, Philine Wangemann, Robert J Morell, Andrew J Griffith   +11 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Macrophages Down-Regulate Gene Expression of Intervertebral Disc Degenerative Markers Under a Pro-inflammatory Microenvironment

Frontiers in Immunology, 2019
Low back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition.
Ana J. Silva, Ana J. Silva, Joana R. Ferreira, Joana R. Ferreira, Joana R. Ferreira, Carla Cunha, Carla Cunha, João V. Corte-Real, João V. Corte-Real, João V. Corte-Real, Mafalda Bessa-Gonçalves, Mafalda Bessa-Gonçalves, Mafalda Bessa-Gonçalves, Mario A. Barbosa, Mario A. Barbosa, Mario A. Barbosa, Susana G. Santos, Susana G. Santos, Susana G. Santos, Raquel M. Gonçalves, Raquel M. Gonçalves, Raquel M. Gonçalves   +21 more
doaj   +1 more source