Results 1 to 10 of about 6,659,351 (174)

CAR T cells produced in vivo to treat cardiac injury

Science, 2022
Description Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al. designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR) T cells that can recognize the ...
Joel G. Rurik, I. Tombácz, A. Yadegari, Pedro O. Méndez Fernández, Swapnil V. Shewale, Li Li, T. Kimura, O. Soliman, Tyler E. Papp, Yin-king Tam, B. Mui, S. Albelda, E. Puré, C. June, H. Aghajanian, D. Weissman, H. Parhiz, J. Epstein   +17 more
semanticscholar   +1 more source

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Briefings Bioinform., 2021
Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response.
D. Maeser, Robert F. Gruener, R. Huang
semanticscholar   +1 more source

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.

New England Journal of Medicine, 2021
BACKGROUND Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in tissues, predominantly the nerves and heart.
J. Gillmore, E. Gane, J. Taubel, J. Kao, M. Fontana, M. Maitland, Jessica Seitzer, D. O’Connell, Kathryn R Walsh, Kristy Wood, Jonathan Phillips, Yuanxin Xu, Adam Amaral, A. Boyd, J. Cehelsky, M. McKee, A. Schiermeier, O. Harari, A. Murphy, C. Kyratsous, B. Zambrowicz, Randy Soltys, D. Gutstein, J. Leonard, L. Sepp-Lorenzino, D. Lebwohl   +25 more
semanticscholar   +1 more source

Macrophage plasticity and polarization: in vivo veritas.

Journal of Clinical Investigation, 2012
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes ...
A. Sica, A. Mantovani
semanticscholar   +1 more source

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of ...
Goberdhan P Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. Medrano, M. Linskens, I. Rubelj, O. Pereira-smith   +9 more
semanticscholar   +1 more source

Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

Science, 2005
Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage.
A. Nimmerjahn, F. Kirchhoff, F. Helmchen
semanticscholar   +1 more source

Plasma and cavitation dynamics during pulsed laser microsurgery in vivo [PDF]

Phys. Rev. Lett. 99, 158104 (2007), 2007
We compare the plasma and cavitation dynamics underlying pulsed laser microsurgery in water and in fruit fly embryos (in vivo) - specifically for nanosecond pulses at 355 and 532 nm. We find two key differences. First, the plasma-formation thresholds are lower in vivo - especially at 355 nm - due to the presence of endogenous chromophores that serve as
arxiv   +1 more source

Homeostatic plasticity and external input shape neural network dynamics [PDF]

Phys. Rev. X 8, 031018 (2018), 2018
In vitro and in vivo spiking activity clearly differ. Whereas networks in vitro develop strong bursts separated by periods of very little spiking activity, in vivo cortical networks show continuous activity. This is puzzling considering that both networks presumably share similar single-neuron dynamics and plasticity rules. We propose that the defining
arxiv   +1 more source

Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America, 2000
Dentinal repair in the postnatal organism occurs through the activity of specialized cells, odontoblasts, that are thought to be maintained by an as yet undefined precursor population associated with pulp tissue.
S. Gronthos, M. Mankani, J. Brahim, P. Robey, S. Shi   +4 more
semanticscholar   +1 more source

In Vivo Wireless Channel Modeling [PDF]

Advances in Body-Centric Wireless Communication: Applications and state-of-the-art, Inst. Eng. Technol. (IET), Jun. 2016, ch. 7, pp. 187-211, 2019
In this chapter, the state of the art of in vivo wireless channel characterization has been presented. Various studies described in the literature are dedicated to the in vivo communication channel, and they consider different parameters in studying various anatomical regions.
arxiv   +1 more source