Results 1 to 10 of about 7,607,147 (352)

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

Scientific Reports, 2020
A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put forward with compelling justification.
Michael Mildner, Adelheid Elbe-Bürger
exaly   +2 more sources

In vivo genome editing using Staphylococcus aureus Cas9

Nature, 2015
The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly ...
F Ann Ran, Le Cong, Winston X Yan
exaly   +2 more sources

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Briefings Bioinform., 2021
Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response.
D. Maeser, Robert F. Gruener, R. Huang
semanticscholar   +1 more source

Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI

npj Parkinson's Disease, 2021
Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN).
Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garraux   +10 more
doaj   +1 more source

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.

New England Journal of Medicine, 2021
BACKGROUND Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in tissues, predominantly the nerves and heart.
J. Gillmore, E. Gane, J. Taubel, J. Kao, M. Fontana, M. Maitland, Jessica Seitzer, D. O’Connell, Kathryn R Walsh, Kristy Wood, Jonathan Phillips, Yuanxin Xu, Adam Amaral, A. Boyd, J. Cehelsky, M. McKee, A. Schiermeier, O. Harari, A. Murphy, C. Kyratsous, B. Zambrowicz, Randy Soltys, D. Gutstein, J. Leonard, L. Sepp-Lorenzino, D. Lebwohl   +25 more
semanticscholar   +1 more source

Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study

Brain and Behavior, 2023
Introduction Quantitative MRI quantifies tissue microstructural properties and supports the characterization of cerebral tissue damages. With an MPM protocol, 4 parameter maps are constructed: MTsat, PD, R1 and R2*, reflecting tissue physical properties ...
Nora Vandeleene, Camille Guillemin, Solène Dauby, Florence Requier, Maëlle Charonitis, Daphne Chylinski, Evelyne Balteau, Pierre Maquet, Emilie Lommers, Christophe Phillips   +9 more
doaj   +1 more source

Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task

Communications Biology, 2023
Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas.
Ilenia Paparella, Islay Campbell, Roya Sharifpour, Elise Beckers, Alexandre Berger, Jose Fermin Balda Aizpurua, Ekaterina Koshmanova, Nasrin Mortazavi, Puneet Talwar, Christian Degueldre, Laurent Lamalle, Siya Sherif, Christophe Phillips, Pierre Maquet, Gilles Vandewalle   +14 more
doaj   +1 more source

Author Correction: Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations

Communications Biology, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01995 ...
Maxime Van Egroo, Justinas Narbutas, Daphne Chylinski, Pamela Villar González, Pouya Ghaemmaghami, Vincenzo Muto, Christina Schmidt, Giulia Gaggioni, Gabriel Besson, Xavier Pépin, Elif Tezel, Davide Marzoli, Caroline Le Goff, Etienne Cavalier, André Luxen, Eric Salmon, Pierre Maquet, Mohamed Ali Bahri, Christophe Phillips, Christine Bastin, Fabienne Collette, Gilles Vandewalle   +21 more
doaj   +1 more source

In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men

Scientific Reports, 2023
The regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain largely unexplored.
Puneet Talwar, Michele Deantoni, Maxime Van Egroo, Vincenzo Muto, Daphne Chylinski, Ekaterina Koshmanova, Mathieu Jaspar, Christelle Meyer, Christian Degueldre, Christian Berthomier, André Luxen, Eric Salmon, Fabienne Collette, D.-J. Dijk, Christina Schmidt, Christophe Phillips, Pierre Maquet, Siya Sherif, Gilles Vandewalle   +18 more
doaj   +1 more source

CAR T cells produced in vivo to treat cardiac injury

Science, 2022
Description Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al. designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR) T cells that can recognize the ...
Joel G. Rurik, I. Tombácz, A. Yadegari, Pedro O. Méndez Fernández, Swapnil V. Shewale, Li Li, T. Kimura, O. Soliman, Tyler E. Papp, Yin-king Tam, B. Mui, S. Albelda, E. Puré, C. June, H. Aghajanian, D. Weissman, H. Parhiz, J. Epstein   +17 more
semanticscholar   +1 more source