Results 31 to 40 of about 5,451,159 (308)

CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma

OncoImmunology, 2021
Multiple myeloma (MM) is a hematological malignancy characterized by the presence of clonal plasma cells in the bone marrow niche. Despite significant therapeutic advances, MM remains incurable for the majority of patients. Targeted radionuclide therapy (
Kim De Veirman, Janik Puttemans, Ahmet Krasniqi, Thomas Ertveldt, Heleen Hanssens, Ema Romao, Dirk Hose, Cleo Goyvaert, Philip Vlummens, Serge Muyldermans, Karine Breckpot, Frank Bruchertseifer, Alfred Morgenstern, Matthias D’Huyvetter, Nick Devoogdt   +14 more
doaj   +1 more source

A multicontrast MR atlas of the Wistar rat brain

NeuroImage, 2021
We describe a multi-contrast, multi-dimensional atlas of the Wistar rat acquired at microscopic spatial resolution using magnetic resonance histology (MRH). Diffusion weighted images, and associated scalar images were acquired of a single specimen with a
G. Allan Johnson, Rick Laoprasert, Robert J. Anderson, Gary Cofer, James Cook, Forrest Pratson, Leonard E. White   +6 more
doaj   +1 more source

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Belcher, P.R., Caslake, M.J., Chaudhry, M.A., Day, S., Muriithi, E.W., Wheatley, D.J.   +5 more
core   +1 more source

Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. [PDF]

, 2017
BackgroundAlthough the contrast-enhancing (CE) lesion on T1-weighted MR images is widely used as a surrogate for glioblastoma (GBM), there are also non-enhancing regions of infiltrative tumor within the T2-weighted lesion, which elude radiologic ...
Autry, Adam, Cha, Soonmee, Chang, Susan M, Lupo, Janine M, Maleschlijski, Stojan, Molinaro, Annette M, Nelson, Sarah J, Phillips, Joanna J, Roy, Ritu   +8 more
core   +2 more sources

In Vivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis. [PDF]

, 2018
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK), and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study.
Burton, Matthew J, Chidambaram, Jaya D, Elakkiya, Shanmugam, Lalitha, Prajna, Lanjewar, Shruti, Macleod, David, Palepu, Srikanthi, Prajna, Namperumalsamy V, Shah, Manisha   +8 more
core   +1 more source

Learnings and challenges to deploy an interprofessional and independent medical education programme to a new audience

Journal of European CME, 2017
The importance of interprofessional education (IPE) in continuing medical education and professional development has long been recognised by health organisations and academic societies, benefiting not only patient outcomes and interprofessional ...
Mieke L. Van Driel, Treasure M. McGuire, Richard Stark, Patrice Lazure, Tina Garcia, Lisa Sullivan   +5 more
doaj   +1 more source

Predicting unipolar and bipolar depression using inflammatory markers, neuroimaging and neuropsychological data: a machine learning study

European Psychiatry, 2023
Introduction About 60% of bipolar disorder (BD) cases are initially misdiagnosed as major depressive disorder (MDD), preventing BD patients from receiving appropriate treatment.
L. Raffaelli, F. Colombo, F. Calesella, L. Fortaner-Uya, I. Bollettini, C. Lorenzi, E. Maggioni, E. Tassi, S. Poletti, R. Zanardi, F. Attanasio, F. Benedetti, B. Vai   +12 more
doaj   +1 more source

The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery

Biomolecules, 2021
Intraoperative guidance using targeted fluorescent tracers can potentially provide surgeons with real-time feedback on the presence of tumor tissue in resection margins.
Pieterjan Debie, Noemi B. Declerck, Danny van Willigen, Celine M. Huygen, Bieke De Sloovere, Lukasz Mateusiak, Jessica Bridoux, Janik Puttemans, Nick Devoogdt, Fijs W. B. van Leeuwen, Sophie Hernot   +10 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases

Pharmaceutics, 2019
Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities.
Janik Puttemans, Tony Lahoutte, Matthias D’Huyvetter, Nick Devoogdt   +3 more
doaj   +1 more source