Results 11 to 20 of about 7,607,147 (352)

CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

Scientific Reports, 2021
Phenylketonuria (PKU) is an autosomal recessive inborn error of l-phenylalanine (Phe) metabolism. It is caused by a partial or complete deficiency of the enzyme phenylalanine hydroxylase (PAH), which is necessary for conversion of Phe to tyrosine (Tyr ...
Kuldeep Singh, Cathleen S. Cornell, Robert Jackson, Mostafa Kabiri, Michael Phipps, Mitul Desai, Robert Fogle, Xiaoyou Ying, Gulbenk Anarat-Cappillino, Sarah Geller, Jennifer Johnson, Errin Roberts, Katie Malley, Tim Devlin, Matthew DeRiso, Patricia Berthelette, Yao V. Zhang, Susan Ryan, Srinivas Rao, Beth L. Thurberg, Dinesh S. Bangari, Sirkka Kyostio-Moore   +21 more
doaj   +1 more source

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies

Scientific Reports, 2022
N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta, Paolo Novelli, Yoann Joyard, Nicolas Maindron, Patrick Riss, Sylvestre Dammicco   +5 more
doaj   +1 more source

Influence of sperm cryopreservation on sperm motility and proAKAP4 concentration in mice

Reproductive Medicine and Biology, 2022
Background The protein proAKAP4 is crucial for sperm motility and has been suggested as an indicator of male fertility. We determined the relationship between proAKAP4 concentration and sperm motility parameters in mice, and investigated the effects of ...
Auke Boersma, Jasmin Primus, Bettina Wagner, Veronika Broukal, Lill Andersen, Barbara Pachner, Maik Dahlhoff, Thomas Rülicke, Kerstin E. Auer   +8 more
doaj   +1 more source

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men

NeuroImage, 2023
Sleep has been suggested to contribute to myelinogenesis and associated structural changes in the brain. As a principal hallmark of sleep, slow-wave activity (SWA) is homeostatically regulated but also differs between individuals. Besides its homeostatic
Michele Deantoni, Marion Baillet, Gregory Hammad, Christian Berthomier, Mathilde Reyt, Mathieu Jaspar, Christelle Meyer, Maxime Van Egroo, Puneet Talwar, Eric Lambot, Sarah L. Chellappa, Christian Degueldre, André Luxen, Eric Salmon, Evelyne Balteau, Christophe Phillips, Derk-Jan Dijk, Gilles Vandewalle, Fabienne Collette, Pierre Maquet, Vincenzo Muto, Christina Schmidt   +21 more
doaj   +1 more source

Brain correlates of perceived cognitive impairment after covid-19 infection: a multimodal MRI study.

European Psychiatry, 2023
Introduction Many different long-term neuropsychiatric sequelae of the novel Coronavirus have been described after the pandemic outbreak. One of the most common symptoms in the months following infection is related to “brain fog”.
V. Bettonagli, M. Paolini, M. Palladini, M. G. Mazza, P. Rovere Guerini, S. Poletti, F. Benedetti   +6 more
doaj   +1 more source

Bone in vivo: Surface mapping technique [PDF]

, 2010
Bone surface mapping technique is proposed on the bases of two kinds of uniqueness of bone in vivo, (i) magnitude of the principal moments of inertia, (ii) the direction cosines of principal axes of inertia relative to inertia reference frame.
Fan, Yifang, Fan, Yubo, Li, Zhiyu, Lv, Changsheng, Zhang, Bo   +4 more
core   +13 more sources

The impact of percutaneous epididymal sperm aspiration on sperm quality in mice

Reproduction and Fertility, 2023
In laboratory mice, sperm quality is usually assessed in spermatozoa collected from the cauda epididymidis of freshly sacrificed males. Percutaneous epididymal sperm aspiration (PESA) is a non-terminal alternative that would allow repeated sperm ...
Lisa Windhofer, Auke Boersma, Maik Dahlhoff, Thomas Rülicke, Kerstin E Auer   +4 more
doaj   +1 more source

Light as a Modulator of Non-Image-Forming Brain Functions—Positive and Negative Impacts of Increasing Light Availability

Clocks & Sleep, 2023
Light use is rising steeply, mainly because of the advent of light-emitting diode (LED) devices. LEDs are frequently blue-enriched light sources and may have different impacts on the non-image forming (NIF) system, which is maximally sensitive to blue ...
Islay Campbell, Roya Sharifpour, Gilles Vandewalle   +2 more
doaj   +1 more source

LV305, a dendritic cell-targeting integration-deficient ZVexTM-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response

Molecular Therapy: Oncolytics, 2016
We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein.
Tina Chang Albershardt, David James Campbell, Andrea Jean Parsons, Megan Merrill Slough, Jan ter Meulen, Peter Berglund   +5 more
doaj   +1 more source

The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs

Frontiers in Pharmacology, 2020
AimsTo describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant ...
Jonas Goldin Diness, Jeppe Egedal Kirchhoff, Tobias Speerschneider, Tobias Speerschneider, Lea Abildgaard, Nils Edvardsson, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Bo Hjorth Bentzen   +10 more
doaj   +1 more source